Indole-3-Carbinol and Its Role in Chronic Diseases (Q38965200)

8 September 2017

1 reference

title

Indole-3-Carbinol and Its Role in Chronic Diseases (English)

1 reference

8 September 2017

0 references

Barbara Licznerska

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Wanda Baer-Dubowska

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

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publication date

1 January 2016

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Advances in Experimental Medicine and Biology

8 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

928

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

131-154

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

1 June 2020

cites work

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Molecular targets and anticancer potential of indole-3-carbinol and its derivatives

21 January 2018

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Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy

21 January 2018

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Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice

21 January 2018

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Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice

21 January 2018

1 reference

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Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol

21 January 2018

1 reference

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Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol

21 January 2018

1 reference

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3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

21 January 2018

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Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.

21 January 2018

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Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells

21 January 2018

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Global estimates of cancer prevalence for 27 sites in the adult population in 2008.

21 January 2018

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Cancer epigenetics: above and beyond

21 January 2018

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Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

21 January 2018

1 reference

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Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes

21 January 2018

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Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo

21 January 2018

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Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells

21 January 2018

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3,3′-diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model

21 January 2018

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Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice

21 January 2018

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Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation

21 January 2018

1 reference

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Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Endocrine treatment in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Androgen receptor in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

3,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Genistein-selenium combination induces growth arrest in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

The nuclear factor NF-kappaB pathway in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

miR-146a suppresses invasion of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3'-diindolylmethene in human breast epithelial cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cruciferous vegetables and colo-rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Defective gap junctional intercellular communication in the carcinogenic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

A phase I study of indole-3-carbinol in women: tolerability and effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cellular signaling perturbation by natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Estrogenic status modulates aryl hydrocarbon receptor--mediated hepatic gene expression and carcinogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cabbage Juices and Indoles Modulate the Expression Profile of AhR, ERα, and Nrf2 in Human Breast Cell Lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Reduction of oxidative DNA-damage in humans by brussels sprouts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Role of estrogen receptor alpha in human cervical cancer-associated fibroblasts: a transcriptomic study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Cruciferous indole-3-carbinol inhibits apolipoprotein B secretion in HepG2 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Indole-3-carbinol and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Brassica vegetables and cancer prevention. Epidemiology and mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Dose-ranging study of indole-3-carbinol for breast cancer prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

Anti-proliferative and pro-apoptotic effects of 3,3'-diindolylmethane in human cervical cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-41334-1_6

10.1007/978-3-319-41334-1_6

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27671815%20AND%20SRC:MED&resulttype=core&format=json