Uridine Phosphorylase from Trypanosoma cruzi: Kinetic and Chemical Mechanisms (Q38942581)

7 September 2017

Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms (English)

1 reference

7 September 2017

Uridine Phosphorylase from Trypanosoma cruzi: Kinetic and Chemical Mechanisms (English)

1 reference

12 December 2024

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Vern L Schramm

1 reference

7 September 2017

Rafael G. Silva

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21932786

12 December 2024

language of work or name

English

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publication date

27 September 2011

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full work available at URL

7 September 2017

https://europepmc.org/articles/pmc3208269?pdf=render

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21932786

https://europepmc.org/articles/PMC3208269

12 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21932786

https://europepmc.org/articles/PMC3208269?pdf=render

12 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21932786

https://doi.org/10.1021/bi2013382

12 December 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21932786

https://pubs.acs.org/doi/pdf/10.1021/bi2013382

12 December 2024

1 reference

12 December 2024

1 reference

7 September 2017

1 reference

7 September 2017

1 reference

7 September 2017

9158-9166

1 reference

The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases

7 September 2017

1 reference

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Glycal Formation in Crystals of Uridine Phosphorylase ,

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

9 September 2017

1 reference

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Toward a detailed understanding of base excision repair enzymes: transition state and mechanistic analyses of N-glycoside hydrolysis and N-glycoside transfer

9 September 2017

1 reference

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Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues

9 September 2017

1 reference

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Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene

9 September 2017

1 reference

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Bacterial uracil riboside phosphorylase

9 September 2017

1 reference

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Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

9 September 2017

1 reference

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Structural analyses reveal two distinct families of nucleoside phosphorylases

9 September 2017

1 reference

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The expression of isotope effects on enzyme-catalyzed reactions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Use of isotope effects to elucidate enzyme mechanisms

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Determination of dissociation constants and specific rate constants of enzyme-substrate (or protein-ligand) interactions from rapid reaction kinetic data

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Transition-state structure of human 5'-methylthioadenosine phosphorylase

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Rapid kinetic analysis of mechanochemical adenosinetriphosphatases.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Steady-state analysis of kinetic isotope effects in enzymic reactions

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Evolution of enzyme function and the development of catalytic efficiency

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Transition-State Analysis of Trypanosoma cruzi Uridine Phosphorylase-Catalyzed Arsenolysis of Uridine

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy

21 August 2018

1 reference

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Transition-state geometry measurements from (13)c isotope effects. The experimental transition state for the epoxidation of alkenes with oxaziridines

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Enzyme-catalyzed uridine phosphorolysis: SN2 mechanism with phosphate activation by desolvation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose-6-phosphate dehydrogenase.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

Uridine phosphorylase from Escherichia coli B.: Kinetic studies on the mechanism of catalysis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208269

The use of pH studies to determine chemical mechanisms of enzyme-catalyzed reactions

21 August 2018

1 reference

12 December 2020

The use of isotope effects to determine transition-state structure for enzymic reactions

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12 December 2020

Synthesis of nucleotides with specific radiolabels in ribose. Primary 14C and secondary 3H kinetic isotope effects on acid-catalyzed glycosidic bond hydrolysis of AMP, dAMP, and inosine

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12 December 2020

Uridine phosphorylase from Schistosoma mansoni

1 reference

12 December 2020

Uridine phosphorylase from Hymenolepis diminuta (Cestoda): kinetics and inhibition by pyrimidine nucleoside analogs

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12 December 2020

Mechanism from isotope effects

1 reference

12 December 2020

Enzymatic transition-state analysis and transition-state analogs

1 reference

12 December 2020

Cytoplsmic uridine phosphorylase of rat liver. Characterization and kinetics

1 reference

12 December 2020

Mechanism from isotope effects

1 reference

Theoretical secondary kinetic isotope effects and the interpretation of transition state geometries. 1. The Cope rearrangement

12 December 2024

1 reference

12 December 2024

Identifiers

DOI

10.1021/BI2013382

1 reference

7 September 2017

1 reference

7 September 2017

1 reference