Site-selective incorporation and ligation of protein aldehydes (Q38887360)

7 September 2017

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title

Site-selective incorporation and ligation of protein aldehydes (English)

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7 September 2017

Martin A Fascione

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Richard J Spears

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7 September 2017

publication date

6 July 2016

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Organic and Biomolecular Chemistry

7 September 2017

published in

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7 September 2017

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7 September 2017

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7 September 2017

page(s)

7622-7638

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Size comparison between proteins PEGylated with branched and linear poly(ethylene glycol) molecules

7 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

In vivo imaging of membrane-associated glycans in developing zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Aldehyde PEGylation Kinetics: A Standard Protein versus a Pharmaceutically Relevant Single Chain Variable Fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Efficient site-specific labeling of proteins via cysteines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A three-component Mannich-type reaction for selective tyrosine bioconjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Selective tryptophan modification with rhodium carbenoids in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Bioconjugation via azide-Staudinger ligation: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Advances in chemical protein modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

N-Terminal peptide aldehydes as electrophiles in combinatorial solid phase synthesis of novel peptide isosteres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Rethinking amide bond synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Serine/threonine ligation for the chemical synthesis of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

KAHA ligations that form aspartyl aldehyde residues as synthetic handles for protein modification and purification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Organic chemistry of periodates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

α-Oxo aldehyde or glyoxylyl group chemistry in peptide bioconjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A novel method for the rational construction of well-defined immunogens: the use of oximation to conjugate cholera toxin B subunit to a peptide-polyoxime complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A protein-based pentavalent inhibitor of the cholera toxin B-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

N-terminal protein modification through a biomimetic transamination reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Optimization of a biomimetic transamination reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-specific protein transamination using N-methylpyridinium-4-carboxaldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Optimization and expansion of a site-selective N-methylpyridinium-4-carboxaldehyde-mediated transamination for bacterially expressed proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Introducing genetically encoded aldehydes into proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Protein glycoengineering enabled by the versatile synthesis of aminooxy glycans and the genetically encoded aldehyde tag

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Chemoenzymatic Fc glycosylation via engineered aldehyde tags.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A Pictet-Spengler ligation for protein chemical modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Regio- and chemoselective covalent immobilization of proteins through unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Exploiting the Substrate Tolerance of Farnesyltransferase for Site-Selective Protein Derivatization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Selective labeling of polypeptides using protein farnesyltransferase via rapid oxime ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Chemoenzymatic reversible immobilization and labeling of proteins without prior purification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Simultaneous dual protein labeling using a triorthogonal reagent

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Engineering protein farnesyltransferase for enzymatic protein labeling applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Expanding the genetic code of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Addition of the keto functional group to the genetic code of Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

The genetic incorporation of thirteen novel non-canonical amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A genetically encoded aldehyde for rapid protein labelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Genetic introduction of a diketone-containing amino acid into proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A method for the generation of glycoprotein mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A general approach to site-specific antibody drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Water-soluble organocatalysts for hydrazone and oxime formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Rapid oxime and hydrazone ligations with aromatic aldehydes for biomolecular labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Nucleophilic catalysis of oxime ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Enhanced catalysis of oxime-based bioconjugations by substituted anilines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

N-terminal labeling of proteins by the Pictet-Spengler reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Protein modification by strain-promoted alkyne-nitrone cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Kinetics studies of rapid strain-promoted [3 + 2]-cycloadditions of nitrones with biaryl-aza-cyclooctynone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Functionalization of peptides and proteins by Mukaiyama aldol reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Indium mediated allylation in peptide and protein functionalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Enabling Wittig reaction on site-specific protein modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Rapid, hydrolytically stable modification of aldehyde-terminated proteins and phage libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Capture of peptides with N-terminal serine and threonine: a sequence-specific chemical method for Peptide mixture simplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

A CXCR4-targeted site-specific antibody-drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Oxime conjugation in protein chemistry: from carbonyl incorporation to nucleophilic catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Hydrolytic stability of hydrazones and oximes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Boronic acids facilitate rapid oxime condensations at neutral pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

New organocatalyst scaffolds with high activity in promoting hydrazone and oxime formation at neutral pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Nucleophilic reactivities of hydrazines and amines: the futile search for the α-effect in hydrazine reactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Click chemistry and bioorthogonal reactions: unprecedented selectivity in the labeling of biological molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

N-Terminal dual protein functionalization by strain-promoted alkyne-nitrone cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Strain-promoted cycloadditions involving nitrones and alkynes--rapid tunable reactions for bioorthogonal labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Mukaiyama Aldol Reactions in Aqueous Media

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Über Triphenyl-phosphin-methylene als olefinbildende Reagenzien (I. Mitteil

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Stabilized Wittig olefination for bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Chemistry in living systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

Bioorthogonal Reactions for Labeling Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC6OB00778C

21 January 2018

Identifiers

DOI

10.1039/C6OB00778C

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7 September 2017

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