LRRK2 and Autophagy (Q38869514)

7 September 2017

title

LRRK2 and Autophagy (English)

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7 September 2017

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Claudia Manzoni

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7 September 2017

Patrick A Lewis

series ordinal

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7 September 2017

publication date

1 January 2017

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7 September 2017

published in

Advances in neurobiology

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7 September 2017

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7 September 2017

page(s)

89-105

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Mammalian autophagy: core molecular machinery and signaling regulation

7 September 2017

cites work

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It's a cell-eat-cell world: autophagy and phagocytosis.

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Autophagy at the crossroads of catabolism and anabolism

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An overview of autophagy: morphology, mechanism, and regulation

21 January 2018

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

21 January 2018

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The Beclin 1 network regulates autophagy and apoptosis

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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How to interpret LC3 immunoblotting

21 January 2018

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Canonical and non-canonical autophagy: variations on a common theme of self-eating?

21 January 2018

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

21 January 2018

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Microautophagy: lesser-known self-eating

21 January 2018

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Emerging themes in bacterial autophagy

21 January 2018

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Mitophagy and Parkinson's disease: the PINK1-parkin link.

21 January 2018

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Molecular mechanism and physiological role of pexophagy

21 January 2018

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Cellular processes associated with LRRK2 function and dysfunction

21 January 2018

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LRRK2 and human disease: a complicated question or a question of complexes?

21 January 2018

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

21 January 2018

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The genetics of Parkinson's syndromes: a critical review

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation

21 January 2018

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

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The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

21 January 2018

1 reference

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Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy

21 January 2018

1 reference

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Inhibition of LRRK2 kinase activity stimulates macroautophagy

21 January 2018

1 reference

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The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

21 January 2018

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Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

21 January 2018

1 reference

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GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

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Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

21 January 2018

1 reference

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Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

21 January 2018

1 reference

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

1 reference

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Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

21 January 2018

1 reference

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Mutations in LRRK2 potentiate age-related impairment of autophagic flux

21 January 2018

1 reference

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Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

21 January 2018

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Ancient origin of the Parkinson disease gene LRRK2.

21 January 2018

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

21 January 2018

1 reference

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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

21 January 2018

1 reference

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.

21 January 2018

1 reference

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

1 reference

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Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

21 January 2018

1 reference

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

The link between the GBA gene and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

VPS35 mutations in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

β-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Lysosome-dependent pathways as a unifying theme in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

Genetic, structural, and molecular insights into the function of ras of complex proteins domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-49969-7_5

10.1007/978-3-319-49969-7_5

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference