SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway (Q38825003)

26500049

6 September 2017

title

SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway (English)

1 reference

6 September 2017

L-H Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

H-H Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

M Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

S Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

X-R Jiang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

Y Li

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

G-F Ping

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

Q Cao

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

X Liu

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

W-H Fang

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

G-L Chen

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

J-Y Yang

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

C-F Wu

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

publication date

26 October 2015

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6 September 2017

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14 May 2020

volume

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14 May 2020

issue

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14 May 2020

page(s)

718-728

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

Hallmarks of Cancer: The Next Generation

14 May 2020

cites work

1 reference

21 January 2018

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1 reference

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Apoptosis induced by anticancer drugs

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Oxidative stress in apoptosis and cancer: an update.

21 January 2018

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PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells

21 January 2018

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Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy

21 January 2018

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Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

21 January 2018

1 reference

Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: advantages of multi-target action.

21 January 2018

1 reference

Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones

21 January 2018

1 reference

Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.

21 January 2018

1 reference

Anti-tumour activity of a novel coumarin-chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio

21 January 2018

1 reference

Cellular and molecular mechanisms activating the cell death processes by chalcones: Critical structural effects

21 January 2018

1 reference

Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways

21 January 2018

1 reference

Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer

21 January 2018

1 reference

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling

21 January 2018

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Caspase activation: revisiting the induced proximity model

21 January 2018

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BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}.

21 January 2018

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X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy.

21 January 2018

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Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health

21 January 2018

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Reactive oxygen species in the activation of MAP kinases

21 January 2018

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Apoptotic pathways: paper wraps stone blunts scissors

21 January 2018

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Human caspases: activation, specificity, and regulation

21 January 2018

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Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice

21 January 2018

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Mitochondria as regulators of apoptosis: doubt no more.

21 January 2018

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Signal integration by JNK and p38 MAPK pathways in cancer development

21 January 2018

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ERKs in cancer: friends or foes?

21 January 2018

1 reference

The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells

21 January 2018

1 reference

Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.

21 January 2018

1 reference

Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance

21 January 2018

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Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms

21 January 2018

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Reactive oxygen species: a double-edged sword in oncogenesis

21 January 2018

1 reference

Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer

21 January 2018

1 reference

Induction of hepatoma carcinoma cell apoptosis through activation of the JNK-nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-ROS self-driven death signal circuit

21 January 2018

1 reference

Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway

21 January 2018

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12 December 2020

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs

1 reference

12 December 2020

The impact of reactive oxygen species on anticancer therapeutic strategies

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12 December 2020

Reactive oxygen species signaling in cancer: comparison with aging

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12 December 2020

Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death

1 reference

12 December 2020

HIF-1α knockdown by miRNA decreases survivin expression and inhibits A549 cell growth in vitro and in vivo

1 reference

12 December 2020

Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties

1 reference

12 December 2020

Identifiers

DOI

10.1111/CPR.12226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json

14 May 2020

26500049

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496741&resulttype=core&format=json