Recent early clinical drug development for acute kidney injury. (Q38780169)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997816%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

Recent early clinical drug development for acute kidney injury (English)

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30 March 2020

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30 March 2020

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30 March 2020

Stephen J Wigmore

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30 March 2020

Ewen M Harrison

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30 March 2020

James A Ross

series ordinal

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30 March 2020

Jeremy Hughes

series ordinal

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30 March 2020

language of work or name

English

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publication date

27 December 2016

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997816%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Investigational Drugs

30 March 2020

published in

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30 March 2020

volume

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30 March 2020

issue

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30 March 2020

page(s)

141-154

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What is the real impact of acute kidney injury?

30 March 2020

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Progress in the development of animal models of acute kidney injury and its impact on drug discovery

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Acute kidney injury in 2013: Breaking barriers for biomarkers in AKI--progress at last

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Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients: A Randomized, Controlled, Phase IIB Trial.

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Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial

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A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

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Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury

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siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

21 January 2018

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Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis

21 January 2018

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Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys

21 January 2018

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Protective effect of BMP-7 against aristolochic acid-induced renal tubular epithelial cell injury

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BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

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Bone morphogenetic proteins in development and homeostasis of kidney

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BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells

21 January 2018

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Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

21 January 2018

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Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron

21 January 2018

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Hepatocyte growth factor and the kidney

21 January 2018

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Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death

21 January 2018

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Endogenous hepatocyte growth factor attenuates inflammatory response in glycerol-induced acute kidney injury

21 January 2018

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Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury

21 January 2018

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Late intervention with the small molecule BB3 mitigates postischemic kidney injury

21 January 2018

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Physiology and pathophysiology of heme: implications for kidney disease

21 January 2018

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Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia.

21 January 2018

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Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice

21 January 2018

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Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury

21 January 2018

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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

21 January 2018

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Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation

21 January 2018

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Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

21 January 2018

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Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

21 January 2018

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Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury

21 January 2018

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21 January 2018

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Effects of levosimendan on glomerular filtration rate, renal blood flow, and renal oxygenation after cardiac surgery with cardiopulmonary bypass: a randomized placebo-controlled study

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial.

21 January 2018

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Mesenchymal stem cells in acute kidney injury

21 January 2018

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Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.

21 January 2018

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Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms

21 January 2018

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Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone

21 January 2018

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Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats

21 January 2018

1 reference

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AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality

21 January 2018

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https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model

21 January 2018

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

21 January 2018

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Nonapoptotic cell death in acute kidney injury and transplantation

21 January 2018

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Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival.

21 January 2018

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Synchronized renal tubular cell death involves ferroptosis.

21 January 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

21 January 2018

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Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

21 January 2018

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Necroinflammation in Kidney Disease

21 January 2018

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K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.

21 January 2018

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RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.

21 January 2018

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Emerging key roles for P2X receptors in the kidney

21 January 2018

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P2X7 receptor inhibition protects against ischemic acute kidney injury in mice

21 January 2018

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The emerging role of complement inhibitors in transplantation

21 January 2018

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https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

End Points for Clinical Trials in Acute Kidney Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

Bridging Translation by Improving Preclinical Study Design in AKI

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543784.2017.1274730

10.1080/13543784.2017.1274730

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997816%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27997816%20AND%20SRC:MED&resulttype=core&format=json