Metallothioneins in Prion- and Amyloid-Related Diseases (Q38753411)

6 September 2017

title

Metallothioneins in Prion- and Amyloid-Related Diseases (English)

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6 September 2017

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31 May 2020

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31 May 2020

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31 May 2020

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31 May 2020

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31 May 2020

Vojtěch Adam

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31 May 2020

Petr Babula

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31 May 2020

Pavlína Adam

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26923022%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Cláudio M Gomes

series ordinal

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31 May 2020

publication date

20 February 2016

1 reference

Journal of Alzheimer's Disease

6 September 2017

published in

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31 May 2020

volume

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31 May 2020

issue

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31 May 2020

page(s)

637-656

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Identification of a protein that purifies with the scrapie prion

31 May 2020

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Expression of the gene encoding metallothionein-3 in organs of the reproductive system

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Expression of MT-3 protein in the human kidney

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Hypermethylation of metallothionein-3 CpG island in gastric carcinoma

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Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.

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In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells

21 January 2018

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Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies

21 January 2018

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Identification of mouse brain proteins associated with isoform 3 of metallothionein

21 January 2018

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New Proteins Found Interacting with Brain Metallothionein‐3 Are Linked to Secretion

21 January 2018

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Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors

21 January 2018

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Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

21 January 2018

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Psychological stress induced hippocampus zinc dyshomeostasis and depression-like behavior in rats

21 January 2018

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Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

21 January 2018

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Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

21 January 2018

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Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

21 January 2018

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Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism

21 January 2018

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Rapid exchange of metal between Zn(7)-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes

21 January 2018

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Neuroinflammatory processes in Alzheimer's disease

21 January 2018

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Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

21 January 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

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Copper(I/II), α/β-Synuclein and Amyloid-β: Menage à Trois?

21 January 2018

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21 January 2018

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21 January 2018

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Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease

21 January 2018

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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21 January 2018

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Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

21 January 2018

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Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation

21 January 2018

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Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3

21 January 2018

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Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

21 January 2018

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Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

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The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.

21 January 2018

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Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease

21 January 2018

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Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins

21 January 2018

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Metallothioneins are highly expressed in astrocytes and microcapillaries in Alzheimer's disease

21 January 2018

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Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site

21 January 2018

1 reference

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Molecular biology of prion diseases

21 January 2018

1 reference

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Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein

21 January 2018

1 reference

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Cellular mechanisms of protein aggregate propagation

21 January 2018

1 reference

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Infectious agents and neurodegeneration

21 January 2018

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Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.

21 January 2018

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The cellular prion protein binds copper in vivo

21 January 2018

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Prion protein expression and superoxide dismutase activity

21 January 2018

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Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein

21 January 2018

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Deconvoluting the Cu2+ binding modes of full-length prion protein

21 January 2018

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Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

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Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease

21 January 2018

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Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease

21 January 2018

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

21 January 2018

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PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.

21 January 2018

1 reference

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Prion protein codon 129 polymorphism and risk of Alzheimer disease.

21 January 2018

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Prion protein and Alzheimer disease

21 January 2018

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Induction of cellular prion protein gene expression by copper in neurons

21 January 2018

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Prion protein protects against zinc-mediated cytotoxicity by modifying intracellular exchangeable zinc and inducing metallothionein expression

21 January 2018

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Prion protein facilitates uptake of zinc into neuronal cells

21 January 2018

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Zinc modulates copper coordination mode in prion protein octa-repeat subdomains

21 January 2018

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Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

21 January 2018

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Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface

21 January 2018

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The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II) -thiolate clusters of Zn(7) metallothionein-3.

21 January 2018

1 reference

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Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

21 January 2018

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The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions

21 January 2018

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Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

21 January 2018

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Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

21 January 2018

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Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

21 January 2018

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Comparative pathway and network analysis of brain transcriptome changes during adult aging and in Parkinson's disease

21 January 2018

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An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Heat shock proteins: cellular and molecular mechanisms in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Metallothionein in bovine spongiform encephalopathy

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP).

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Tau protein and tau aggregation inhibitors

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Tau Protein in Familial and Sporadic Diseases

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150984

Α-synuclein misfolding and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Misfolded SOD1 and ALS: zeroing in on mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Recent Insights into the Pathogenesis of Type AA Amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Mechanisms of copper ion mediated Huntington's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

The expression of metallothioneins is diminished in the spinal cords of patients with sporadic ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150984

21 January 2018

Identifiers

DOI

10.3233/JAD-150984

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26923022%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26923022%20AND%20SRC:MED&resulttype=core&format=json