Strategies for target identification of antimicrobial natural products (Q38710256)

5 September 2017

title

Strategies for target identification of antimicrobial natural products (English)

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5 September 2017

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Maya A Farha

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5 September 2017

Eric D Brown

series ordinal

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5 September 2017

publication date

25 January 2016

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5 September 2017

published in

Natural Product Reports

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5 September 2017

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5 September 2017

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5 September 2017

page(s)

668-680

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Natural products as sources of new drugs over the 30 years from 1981 to 2010

5 September 2017

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Drug discovery and natural products: end of an era or an endless frontier?

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Challenges of antibacterial discovery

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Target identification and mechanism of action in chemical biology and drug discovery

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The re-emergence of natural products for drug discovery in the genomics era.

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Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis

21 January 2018

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Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus

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Selective enzyme purification by affinity chromatography

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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

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Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032)

21 January 2018

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Mechanistic studies and biological activity of bioxalomycin alpha 2, a novel antibiotic produced by Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508.

21 January 2018

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Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibiotic.

21 January 2018

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Sequencing technologies - the next generation

21 January 2018

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Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

21 January 2018

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Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis

21 January 2018

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Antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibiotics

21 January 2018

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Broad-spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations

21 January 2018

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Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

21 January 2018

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Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria

21 January 2018

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Efflux-mediated drug resistance in bacteria: an update

21 January 2018

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Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.

21 January 2018

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Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

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Affinity purification in target identification: the specificity challenge

21 January 2018

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Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis

21 January 2018

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Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Biochemical target isolation for novices: affinity-based strategies

21 January 2018

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A new antibiotic kills pathogens without detectable resistance

21 January 2018

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Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy

21 January 2018

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Discovery, biosynthesis, and rational engineering of novel enterocin and wailupemycin polyketide analogues.

21 January 2018

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Bugs, drugs and chemical genomics

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

An array of target-specific screening strains for antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Downregulation of yidC in Escherichia coli by antisense RNA expression results in sensitization to antibacterial essential oils eugenol and carvacrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

21 January 2018

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Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research

21 January 2018

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Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

21 January 2018

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The Pseudomonas aeruginosa PA01 gene collection

21 January 2018

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An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants

21 January 2018

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Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase

21 January 2018

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Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

21 January 2018

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Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

1 reference

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Quantitative phenotyping via deep barcode sequencing.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Confronting the Challenges of Natural Product-Based Antifungal Discovery

21 January 2018

1 reference

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PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

21 January 2018

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Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products

21 January 2018

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Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase.

21 January 2018

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Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I.

21 January 2018

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Quantitative genetic interaction mapping using the E-MAP approach

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Development of ultra-high-density screening tools for microbial "omics".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Functional classification of drugs by properties of their pairwise interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A-102395, a new inhibitor of bacterial translocase I, produced by Amycolatopsis sp. SANK 60206.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A novel assay of bacterial peptidoglycan synthesis for natural product screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Assays for the identification of inhibitors targeting specific translational steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Specific, efficient, and selective inhibition of prokaryotic translation initiation by a novel peptide antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Discovery research: the scientific challenge of finding new antibiotics

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Unconventional screening approaches for antibiotic discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

The discovery of cell wall active antibacterial antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Targets and assays for discovering novel antibacterial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered from Streptomyces lucensis MA7349 using an antisense strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Discovery of FabH/FabF inhibitors from natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A simple, rapid, sensitive method detecting homoserine lactone (HSL)-related compounds in microbial extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Novel whole-cell antibiotic biosensors for compound discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Targeting bacterial central metabolism for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Riboflavin analogs as antiinfectives: occurrence, mode of action, metabolism and resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00127G

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00127G

21 January 2018

Identifiers

DOI

10.1039/C5NP00127G

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5 September 2017

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