LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease. (Q38689010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease (English)

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4 March 2020

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4 March 2020

A Raquel Esteves

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4 March 2020

publication date

8 July 2016

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4 March 2020

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4 March 2020

volume

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4 March 2020

issue

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4 March 2020

page(s)

16-26

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

4 March 2020

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Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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Dynamic and redundant regulation of LRRK2 and LRRK1 expression

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The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

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Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

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The mitochondrial cascade hypothesis for Parkinson's disease

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The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

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LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

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Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

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LRRK2 Promotes Tau Accumulation, Aggregation and Release.

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Leucine-rich repeat kinase 2 associates with lipid rafts

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Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5.

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The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases

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Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

21 January 2018

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Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

21 January 2018

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Maturation of autophagosomes and endosomes: a key role for Rab7.

21 January 2018

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Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

21 January 2018

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LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

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LRRK2 Parkinson disease mutations enhance its microtubule association.

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A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

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RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

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Inhibition of LRRK2 kinase activity stimulates macroautophagy

21 January 2018

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Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

21 January 2018

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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

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Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

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Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

21 January 2018

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21 January 2018

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G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

21 January 2018

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

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Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

21 January 2018

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Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

21 January 2018

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21 January 2018

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

21 January 2018

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LRRK2 transport is regulated by its novel interacting partner Rab32

21 January 2018

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Autophagy gone awry in neurodegenerative diseases

21 January 2018

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GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

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G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.

21 January 2018

1 reference

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Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model

21 January 2018

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Analysis of the LRRK2 G2019S mutation in Alzheimer Disease

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1073858415616558

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740081%20AND%20SRC:MED&resulttype=core&format=json