Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in Alzheimer's disease model. (Q38656547)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Kumar Nikhil

1 reference

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26 March 2020

language of work or name

English

0 references

publication date

27 July 2017

1 reference

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26 March 2020

published in

Journal of Cell Science

1 reference

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26 March 2020

volume

130

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26 March 2020

issue

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26 March 2020

page(s)

3023-3039

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain.

26 March 2020

cites work

1 reference

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31 August 2018

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Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease

31 August 2018

1 reference

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The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma.

31 August 2018

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Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

31 August 2018

1 reference

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TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice

31 August 2018

1 reference

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Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum

31 August 2018

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The role of myocardin-related transcription factor-A in Aβ25-35 induced neuron apoptosis and synapse injury

31 August 2018

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Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior

31 August 2018

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A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

31 August 2018

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Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease

31 August 2018

1 reference

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Ischemic stroke injury is mediated by aberrant Cdk5

31 August 2018

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Cdk5 activity in the brain - multiple paths of regulation

31 August 2018

1 reference

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Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.

31 August 2018

1 reference

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Review of drugs for Alzheimer's disease

31 August 2018

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AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

31 August 2018

1 reference

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Deregulated Cdk5 activity is involved in inducing Alzheimer's disease

31 August 2018

1 reference

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Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

31 August 2018

1 reference

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Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

31 August 2018

1 reference

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Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

31 August 2018

1 reference

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LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

31 August 2018

1 reference

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Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model

31 August 2018

1 reference

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Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

31 August 2018

1 reference

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PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

31 August 2018

1 reference

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Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

31 August 2018

1 reference

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Glutathione‐S‐transferase P1 is a critical regulator of Cdk5 kinase activity

31 August 2018

1 reference

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Mitochondrial Membrane Potential Probes and the Proton Gradient: A Practical Usage Guide

31 August 2018

1 reference

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Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

31 August 2018

1 reference

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Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

31 August 2018

1 reference

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Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35

31 August 2018

1 reference

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Mcl-1; the molecular regulation of protein function

31 August 2018

1 reference

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Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease

31 August 2018

1 reference

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Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease

31 August 2018

1 reference

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MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death

31 August 2018

1 reference

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis

31 August 2018

1 reference

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Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

31 August 2018

1 reference

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Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Rapid turnover of mcl-1 couples translation to cell survival and apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Physiological and morphological characterization of dentate granule cells in the p35 knock-out mouse hippocampus: evidence for an epileptic circuit.

31 August 2018

1 reference

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Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.

31 August 2018

1 reference

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Mental retardation and cardiovascular malformations in NF1 microdeleted patients point to candidate genes in 17q11.2.

31 August 2018

1 reference

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A chemical genetic approach for the identification of direct substrates of protein kinases

31 August 2018

1 reference

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Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway

31 August 2018

1 reference

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31 August 2018

1 reference

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TAT-mediated protein transduction into mammalian cells

31 August 2018

1 reference

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Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Mcl-1 deficiency results in peri-implantation embryonic lethality

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Neuropathological stageing of Alzheimer-related changes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5612176

Cyclin I-Cdk5 governs survival in post-mitotic cells

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28751497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/JCS.205666

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

28751497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28751497%20AND%20SRC:MED&resulttype=core&format=json