ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals. (Q38647566)

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English	ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals.	scientific article

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26 March 2020

ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals (English)

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26 March 2020

Gregers Wegener

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26 March 2020

Sandra Tillmann

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26 March 2020

Vitor Silva Pereira

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26 March 2020

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Nico Liebenberg

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26 March 2020

Anne Karina Christensen

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26 March 2020

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3 August 2017

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26 March 2020

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26 March 2020

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26 March 2020

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26 March 2020

e0182698

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26 March 2020

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3 August 2017

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April 2022 Public Data File from Crossref

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Nitric Oxide Synthase Inhibitors as Antidepressants

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6 September 2017

Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors

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6 September 2017

Exploring Female Mice Interstrain Differences Relevant for Models of Depression

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6 September 2017

Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics

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6 September 2017

Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunction

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6 September 2017

Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections

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6 September 2017

Excitotoxicity and stroke: identifying novel targets for neuroprotection.

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6 September 2017

Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats

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Abnormalities in white matter microstructure associated with chronic ketamine use.

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Comparative evaluation of forced swim test and tail suspension test as models of negative symptom of schizophrenia in rodents

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6 September 2017

The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death

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6 September 2017

The flinders sensitive line rat model of depression--25 years and still producing

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6 September 2017

Cost of disorders of the brain in Europe 2010.

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6 September 2017

Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.

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6 September 2017

Nitric oxide and major depression

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6 September 2017

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

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6 September 2017

Differentiating antidepressants of the future: efficacy and safety

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6 September 2017

The Flinders Sensitive Line rat: a selectively bred putative animal model of depression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

6 September 2017

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

6 September 2017

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

6 September 2017

Nitric oxide synthases: structure, function and inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

6 September 2017

Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors

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6 September 2017

Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study

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6 September 2017

Antidepressant effects of ketamine in depressed patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

6 September 2017

CAPON: A Protein Associated with Neuronal Nitric Oxide Synthase that Regulates Its Interactions with PSD95

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6 September 2017

Involvement of NMDA receptors and L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test

1 reference

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14 September 2017

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

25 September 2017

The Flinders sensitive line rats: a genetic animal model of depression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

25 September 2017

Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

23 June 2018

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95.

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23 June 2018

Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

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23 June 2018

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

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23 June 2018

Selectively bred Wistar–Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants

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23 June 2018

Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain

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23 June 2018

Pharmacological evidence for the involvement of the NMDA receptor and nitric oxide pathway in the antidepressant-like effect of lamotrigine in the mouse forced swimming test

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31 August 2018

Metabolic investigation on ZL006 for the discovery of a potent prodrug for the treatment of cerebral ischemia.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

31 August 2018

Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression.

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31 August 2018

Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke

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31 August 2018

Brain damages in ketamine addicts as revealed by magnetic resonance imaging

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31 August 2018

The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test

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31 August 2018

The economic cost of brain disorders in Europe

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31 August 2018

Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans

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31 August 2018

Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test

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31 August 2018

Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice

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31 August 2018

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

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31 August 2018

A double-blind, placebo-controlled study of memantine in the treatment of major depression

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31 August 2018

Intra- and interstrain differences in models of "behavioral despair".

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31 August 2018

Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats

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31 August 2018

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

31 August 2018

Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5542618

31 August 2018

Nitric oxide synthases: structure, function and inhibition

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0182698

21 January 2018

Using the rat forced swim test to assess antidepressant-like activity in rodents

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0182698

21 January 2018

The tail suspension test: a new method for screening antidepressants in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28771575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma nitrate levels in depressive states

1 reference

https://pubmed.ncbi.nlm.nih.gov/28771575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are Wistar-Kyoto rats a genetic animal model of depression resistant to antidepressants?

1 reference

https://pubmed.ncbi.nlm.nih.gov/28771575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/28771575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0182698

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771575%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771575%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28771575%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

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