In search of predictive endophenotypes in addiction: insights from preclinical research (Q38611507)

Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function

21 January 2018

1 reference

Specious reward: A behavioral theory of impulsiveness and impulse control

21 January 2018

1 reference

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)

21 January 2018

1 reference

21 January 2018

1 reference

Impulsivity predicts the escalation of cocaine self-administration in rats

21 January 2018

1 reference

Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats

21 January 2018

1 reference

Epidemiologic evidence on cocaine use and panic attacks

21 January 2018

1 reference

Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbidity Survey

21 January 2018

1 reference

Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine.

21 January 2018

1 reference

Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice

21 January 2018

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Disrupted social development enhances the motivation for cocaine in rats

21 January 2018

1 reference

Personality Disorder and Dimension Differences Between Type A and Type B Substance Abusers

21 January 2018

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Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice

21 January 2018

1 reference

Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model

21 January 2018

1 reference

Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum

21 January 2018

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High impulsivity predicts the switch to compulsive cocaine-taking

21 January 2018

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Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats.

21 January 2018

1 reference

Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction

21 January 2018

1 reference

High-novelty-preference rats are predisposed to compulsive cocaine self-administration

21 January 2018

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Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

21 January 2018

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Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens

21 January 2018

1 reference

Genetics of impulsive behaviour

21 January 2018

1 reference

A population-specific HTR2B stop codon predisposes to severe impulsivity

21 January 2018

1 reference

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus

21 January 2018

1 reference

Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers.

21 January 2018

1 reference

Decision-making in the adolescent brain

21 January 2018

1 reference

Conditioned place preference: an evaluation of morphine's positive reinforcing properties.

21 January 2018

1 reference

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.

21 January 2018

1 reference

Brief cognitive training interventions in young adulthood promote long-term resilience to drug-seeking behavior.

21 January 2018

1 reference

Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications

21 January 2018

1 reference

Longitudinal changes in adolescent risk-taking: a comprehensive study of neural responses to rewards, pubertal development, and risk-taking behavior

21 January 2018

1 reference

The relationship between impulsive choice and impulsive action: a cross-species translational study.

21 January 2018

1 reference

Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction

21 January 2018

1 reference

Dopaminergic network differences in human impulsivity

21 January 2018

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Individual differences in elevated plus-maze exploration predicted progressive-ratio cocaine self-administration break points in Wistar rats

21 January 2018

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A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats

21 January 2018

1 reference

Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior

21 January 2018

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Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum

21 January 2018

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Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration

21 January 2018

1 reference

Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory.

21 January 2018

1 reference

Role of genotype in the cycle of violence in maltreated children

21 January 2018

1 reference

Molecular neurobiology of drug addiction

21 January 2018

1 reference

The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice

21 January 2018

1 reference

A psychobiological model of temperament and character

21 January 2018

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The relations of trait anxiety, anxiety sensitivity, and sensation seeking to adolescents' motivations for alcohol, cigarette, and marijuana use.

21 January 2018

1 reference

Personality, drug of choice, and comorbid psychopathology among substance abusers.

21 January 2018

1 reference

Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum

21 January 2018

1 reference

A role for repressive histone methylation in cocaine-induced vulnerability to stress

21 January 2018

1 reference

Factors associated with untreated remissions from alcohol abuse or dependence.

21 January 2018

1 reference

Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine

21 January 2018

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Dopamine, serotonin and impulsivity

21 January 2018

1 reference

Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity

21 January 2018

1 reference

Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement

21 January 2018

1 reference

Impulsivity, compulsivity, and top-down cognitive control

21 January 2018

1 reference

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

21 January 2018

1 reference

Impulsivity as a determinant and consequence of drug use: a review of underlying processes

21 January 2018

1 reference

Reinstatement of cocaine-reinforced responding in the rat.

21 January 2018

1 reference

Drug reinstatement of heroin-reinforced responding in the rat.

21 January 2018

1 reference

Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys

21 January 2018

1 reference

Novelty-seeking in rats--biobehavioral characteristics and possible relationship with the sensation-seeking trait in man.

21 January 2018

1 reference

Evidence for addiction-like behavior in the rat.

21 January 2018

1 reference

Alcohol seeking by rats: action or habit?

21 January 2018

1 reference

Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats

21 January 2018

1 reference

Trait impulsivity predicts escalation of sucrose seeking and hypersensitivity to sucrose-associated stimuli.

21 January 2018

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High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats

21 January 2018

1 reference

Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus

21 January 2018

1 reference

High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence

21 January 2018

1 reference

Genetic and environmental influences on the development of alcoholism: resilience vs. risk

21 January 2018

1 reference

Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits

21 January 2018

1 reference

Abnormal brain structure implicated in stimulant drug addiction

21 January 2018

1 reference

Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience

21 January 2018

1 reference

21 January 2018

Varieties of impulsivity

1 reference

Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction

21 January 2018

1 reference

Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour.

21 January 2018

1 reference

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

21 January 2018

1 reference

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On.

21 January 2018

1 reference

What is the prevalence of adult ADHD? Results of a population screen of 966 adults

21 January 2018

1 reference

Attention-deficit/hyperactivity disorder in adults: an overview

21 January 2018

1 reference

Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats

21 January 2018

1 reference

Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction

21 January 2018

1 reference

Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders.

21 January 2018

1 reference

Anxiety sensitivity, controllability, and experiential avoidance and their relation to drug of choice and addiction severity in a residential sample of substance-abusing veterans

21 January 2018

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Predictive validity of the extinction/reinstatement model of drug craving

21 January 2018

1 reference

Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats.

21 January 2018

1 reference

Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen

21 January 2018

1 reference

Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats

21 January 2018

1 reference

Substance use among high-school students: relationships with temperament, personality traits, and parental care perception

21 January 2018

1 reference

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking

21 January 2018

1 reference

Morphine: Conditioned Increases in Self-Administration in Rhesus Monkeys

21 January 2018

1 reference

Drug dependence, crime and personality among female addicts

21 January 2018

1 reference

Personality variables in cocaine- and marijuana-dependent patients

21 January 2018

1 reference

Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems

21 January 2018

1 reference

Rapid-response impulsivity: definitions, measurement issues, and clinical implications

21 January 2018

1 reference

Choice impulsivity: Definitions, measurement issues, and clinical implications.

21 January 2018

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21 January 2018

1 reference

Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior

21 January 2018

1 reference

Sensation seeking and alcohol use: a meta-analytic review

21 January 2018

1 reference

Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues.

21 January 2018

1 reference

Enhanced motivation to self-administer cocaine is predicted by self-grooming behaviour and relates to dopamine release in the rat medial prefrontal cortex and amygdala

21 January 2018

1 reference

Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism.

21 January 2018

1 reference

Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

21 January 2018

1 reference

Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies.

21 January 2018

1 reference

Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex

21 January 2018

1 reference

Brain circuitry and the reinstatement of cocaine-seeking behavior

21 January 2018

1 reference

New medications for drug addiction hiding in glutamatergic neuroplasticity

21 January 2018

1 reference

Transition to addiction is associated with a persistent impairment in synaptic plasticity

21 January 2018

1 reference

Prefrontal synaptic markers of cocaine addiction-like behavior in rats.

21 January 2018

1 reference

Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum

21 January 2018

1 reference

The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence

21 January 2018

1 reference

The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications

21 January 2018

1 reference

Addiction as a self-regulation disorder and the role of self-medication.

21 January 2018

1 reference

Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls

21 January 2018

1 reference

Glutamate and reinstatement

21 January 2018

1 reference

Neuroscience of addiction

21 January 2018

1 reference

Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

21 January 2018

1 reference

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics

21 January 2018

1 reference

Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity

21 January 2018

1 reference

Anxiety sensitivity: a unique predictor of dropout among inner-city heroin and crack/cocaine users in residential substance use treatment

21 January 2018

1 reference

Intense sweetness surpasses cocaine reward

21 January 2018

1 reference

Early social isolation augments alcohol consumption in rats.

21 January 2018

1 reference

mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice

21 January 2018

1 reference

Activity and impulsive action are controlled by different genetic and environmental factors

21 January 2018

1 reference

Rats prone to attribute incentive salience to reward cues are also prone to impulsive action.

21 January 2018

1 reference

Impulsive and self-control choices in opioid-dependent patients and non-drug-using control patients: Drug and monetary rewards

21 January 2018

1 reference

Context-induced relapse to alcohol seeking after punishment in a rat model

21 January 2018

1 reference

Recent developments in animal models of drug relapse.

21 January 2018

1 reference

A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence.

21 January 2018

1 reference

Affective temperaments in heroin addiction

21 January 2018

1 reference

Trait-like impulsivity does not predict escalation of heroin self-administration in the rat.

21 January 2018

1 reference

Intermediate phenotypes and genetic mechanisms of psychiatric disorders

21 January 2018

1 reference

Oral cocaine seeking by rats: action or habit?

21 January 2018

1 reference

Psychiatric aspects of impulsivity.

21 January 2018

1 reference

Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression

21 January 2018

1 reference

High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress

21 January 2018

1 reference

Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences

21 January 2018

1 reference

Acute anxiolytic effects of cocaine: the role of test latency and activity phase

21 January 2018

1 reference

Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking

21 January 2018

1 reference

PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

21 January 2018

1 reference

Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors

21 January 2018

1 reference

Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population

21 January 2018

1 reference

Neurocognitive determinants of novelty and sensation-seeking in individuals with alcoholism

21 January 2018

1 reference

Comorbidity of alcohol and substance dependence with attention-deficit/hyperactivity disorder (ADHD).

21 January 2018

1 reference

The relationship between anxiety levels and outcome of cocaine abuse treatment

21 January 2018

1 reference

Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine

21 January 2018

1 reference

An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.

21 January 2018

1 reference

The neuropharmacology of impulsive behaviour

21 January 2018

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Compulsive drug seeking by rats under punishment: effects of drug taking history

21 January 2018

1 reference

Anxiety increases the place conditioning induced by cocaine in rats.

21 January 2018

1 reference

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.

21 January 2018

1 reference

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

21 January 2018

1 reference

The role of impulsive behavior in drug abuse

21 January 2018

1 reference

Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats

21 January 2018

1 reference

Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats

21 January 2018

1 reference

Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls

21 January 2018

1 reference

Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation

21 January 2018

1 reference

Factors that predict individual vulnerability to amphetamine self-administration.

21 January 2018

1 reference

Risk and Rationality in Adolescent Decision Making: Implications for Theory, Practice, and Public Policy

21 January 2018

1 reference

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

21 January 2018

1 reference

The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry

21 January 2018

1 reference

21 January 2018

Behavioral addictions

1 reference

Limbic-striatal memory systems and drug addiction.

21 January 2018

1 reference

Psychiatric comorbidity in white and African-American illicit substance abusers: evidence for differential etiology

21 January 2018

1 reference

The neural basis of drug craving: an incentive-sensitization theory of addiction

21 January 2018

1 reference

Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'.

21 January 2018

1 reference

On the motivational properties of reward cues: Individual differences.

21 January 2018

1 reference

Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking

21 January 2018

1 reference

Investigating the neurocognitive deficits associated with chronic drug misuse.

21 January 2018

1 reference

Animal models of attention-deficit hyperactivity disorder

21 January 2018

1 reference

Using sensation seeking to target adolescents for substance use interventions.

21 January 2018

1 reference

Individual Variation in the Motivational Properties of Cocaine

21 January 2018

1 reference

Cue-evoked cocaine "craving": role of dopamine in the accumbens core.

21 January 2018

1 reference

Personality variables and self-medication in substance abuse

21 January 2018

1 reference

The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats

21 January 2018

1 reference

A role for synaptic plasticity in the adolescent development of executive function

21 January 2018

1 reference

Impulsivity and methamphetamine use.

21 January 2018

1 reference

The reinstatement model of drug relapse: history, methodology and major findings

21 January 2018

1 reference

Neurobiology of relapse to heroin and cocaine seeking: a review

21 January 2018

1 reference

Personality and substance use disorders: a prospective study.

21 January 2018

1 reference

Subjective dimensions of heroin urges: influence of heroin-related and affectively negative stimuli

21 January 2018

1 reference

How does stress increase risk of drug abuse and relapse?

21 January 2018

1 reference

Comorbidity in a clinical sample of substance abusers

21 January 2018

1 reference

A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues

21 January 2018

1 reference

Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats

21 January 2018

1 reference

Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement

21 January 2018

1 reference

The adolescent brain and age-related behavioral manifestations

21 January 2018

1 reference

Sensation-seeking predicts initiation of daily smoking behavior among American Indian high school students

21 January 2018

1 reference

Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.

21 January 2018

1 reference

An investigation of the interaction between the reinforcing properties of food and ethanol using the place preference paradigm

21 January 2018

1 reference

Motivational effects of opioids: evidence on the role of endorphins in mediating reward or aversion

21 January 2018

1 reference

Genetic architectures of psychiatric disorders: the emerging picture and its implications

21 January 2018

1 reference

Two models of impulsivity: relationship to personality traits and psychopathology.

21 January 2018

1 reference

Five-Factor Model personality profiles of drug users

21 January 2018

1 reference

Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement

21 January 2018

1 reference

Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal.

21 January 2018

1 reference

Sign-tracking predicts increased choice of cocaine over food in rats

21 January 2018

1 reference

Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process

21 January 2018

1 reference

Molecular genetics of addiction vulnerability

21 January 2018

1 reference

The burden of complex genetics in brain disorders

21 January 2018

1 reference

Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation?

21 January 2018

1 reference

Drug seeking becomes compulsive after prolonged cocaine self-administration.

21 January 2018

1 reference

Behavioral and neural mechanisms of compulsive drug seeking

21 January 2018

1 reference

High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction.

21 January 2018

1 reference

Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies.

21 January 2018

1 reference

Neuroscience. To stop or not to stop?

21 January 2018

1 reference

Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex

21 January 2018

1 reference

High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors

21 January 2018

1 reference

Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task.

21 January 2018

1 reference

Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats.

21 January 2018

1 reference

The conditioned place preference is affected by two independent reinforcement processes

21 January 2018

1 reference

Novelty seeking, risk taking, and related constructs as predictors of adolescent substance use: an application of Cloninger's theory.

21 January 2018

1 reference

Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies

21 January 2018

1 reference

Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders

21 January 2018

1 reference

Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task.

21 January 2018

1 reference

Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests

21 January 2018

1 reference

N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking

21 January 2018

1 reference

The impact of gender, depression, and personality on craving

21 January 2018

1 reference

The psychophysiology of sensation seeking

21 January 2018

1 reference

Sensation seeking and psychopathology

21 January 2018

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