Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies (Q38596601)

4 September 2017

title

Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies (English)

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4 September 2017

main subject

autism spectrum disorder

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Michael W Nestor

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4 September 2017

Andre W Phillips

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4 September 2017

Elena Artimovich

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4 September 2017

Jonathan E Nestor

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4 September 2017

John P Hussman

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4 September 2017

Gene J Blatt

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4 September 2017

language of work or name

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1 October 2015

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4 September 2017

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4 September 2017

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4 September 2017

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4 September 2017

page(s)

513-535

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High content screening applied to large-scale cell biology

4 September 2017

cites work

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The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment

21 January 2018

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Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

21 January 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model

21 January 2018

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Discovering Small Molecules to Control Stem Cell Fate

21 January 2018

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Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors

21 January 2018

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A clinicopathological study of autism

21 January 2018

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High-content screening of small compounds on human embryonic stem cells.

21 January 2018

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The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels

21 January 2018

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Image-based transcriptomics in thousands of single human cells at single-molecule resolution

21 January 2018

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Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

21 January 2018

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Genetic advances in autism: heterogeneity and convergence on shared pathways

21 January 2018

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The neuropathology of autism

21 January 2018

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Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study

21 January 2018

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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

21 January 2018

1 reference

ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease

21 January 2018

1 reference

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening

21 January 2018

1 reference

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

21 January 2018

1 reference

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

21 January 2018

1 reference

Modelling schizophrenia using human induced pluripotent stem cells

21 January 2018

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Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

21 January 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

21 January 2018

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Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

21 January 2018

1 reference

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

21 January 2018

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Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration

21 January 2018

1 reference

Ultrasensitive fluorescent proteins for imaging neuronal activity

21 January 2018

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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

21 January 2018

1 reference

Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

21 January 2018

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Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

21 January 2018

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Direct conversion of fibroblasts into functional astrocytes by defined transcription factors

21 January 2018

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Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders

21 January 2018

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Overexpression of polysialylated neural cell adhesion molecule improves the migration capacity of induced pluripotent stem cell-derived oligodendrocyte precursors

21 January 2018

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FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

21 January 2018

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hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells

21 January 2018

1 reference

Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells

21 January 2018

1 reference

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

21 January 2018

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Adapting human pluripotent stem cells to high-throughput and high-content screening

21 January 2018

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Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

21 January 2018

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

21 January 2018

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Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

21 January 2018

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Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals

21 January 2018

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Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats

21 January 2018

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Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo

21 January 2018

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Efficient derivation of functional floor plate tissue from human embryonic stem cells

21 January 2018

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The development and application of optogenetics

21 January 2018

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Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures

21 January 2018

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Genetics of austim: complex aetiology for a heterogeneous disorder

21 January 2018

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

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The Lifetime Distribution of the Incremental Societal Costs of Autism

21 January 2018

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Fibroblast phenotype in male carriers of FMR1 premutation alleles

21 January 2018

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Novel de novo SHANK3 mutation in autistic patients

21 January 2018

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Autism: many genes, common pathways?

21 January 2018

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Drug discovery for autism spectrum disorder: challenges and opportunities

21 January 2018

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Autism and Asperger syndrome: coexistence with other clinical disorders

21 January 2018

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Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2.

21 January 2018

1 reference

Forcing cells to change lineages

21 January 2018

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Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders.

21 January 2018

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Imaging calcium in neurons

21 January 2018

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Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

21 January 2018

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Neural stem cell engraftment and myelination in the human brain

21 January 2018

1 reference

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

21 January 2018

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Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice

21 January 2018

1 reference

Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity.

21 January 2018

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Directing astroglia from the cerebral cortex into subtype specific functional neurons

21 January 2018

1 reference

Development and applications of CRISPR-Cas9 for genome engineering

21 January 2018

1 reference

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

21 January 2018

1 reference

Generation of an ICF syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system

21 January 2018

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CRISPR/Cas, the immune system of bacteria and archaea

21 January 2018

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Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism

21 January 2018

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A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

21 January 2018

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Elevated rates of testosterone-related disorders in women with autism spectrum conditions

21 January 2018

1 reference

The use of induced pluripotent stem cells in drug development

21 January 2018

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The contribution of de novo coding mutations to autism spectrum disorder

21 January 2018

1 reference

Size bias of fragile X premutation alleles in late-onset movement disorders.

21 January 2018

1 reference

Single action potentials and subthreshold electrical events imaged in neurons with a fluorescent protein voltage probe.

21 January 2018

1 reference

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

21 January 2018

1 reference

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

21 January 2018

1 reference

Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational study

21 January 2018

1 reference

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

21 January 2018

1 reference

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

21 January 2018

1 reference

Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.

21 January 2018

1 reference

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions

21 January 2018

1 reference

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

21 January 2018

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Specification of transplantable astroglial subtypes from human pluripotent stem cells

21 January 2018

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Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

21 January 2018

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Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

21 January 2018

1 reference

Generation of cerebral organoids from human pluripotent stem cells

21 January 2018

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Cerebral organoids model human brain development and microcephaly

21 January 2018

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Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels

21 January 2018

1 reference

Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds

21 January 2018

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Neural lineage differentiation of embryonic stem cells within alginate microbeads

21 January 2018

1 reference

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

21 January 2018

1 reference

Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.

21 January 2018

1 reference

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

21 January 2018

1 reference

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective

21 January 2018

1 reference

Identification of glutamate residues important for catalytic activity or thermostability of a truncated Bacillus sp. strain TS-23 alpha-amylase by site-directed mutagenesis.

21 January 2018

1 reference

Signaling defects in iPSC-derived fragile X premutation neurons

21 January 2018

1 reference

A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes

21 January 2018

1 reference

Efficient neuronal differentiation and maturation of human pluripotent stem cells encapsulated in 3D microfibrous scaffolds

21 January 2018

1 reference

A genome-wide association study of autism reveals a common novel risk locus at 5p14.1

21 January 2018

1 reference

Optogenetic probing of functional brain circuitry

21 January 2018

1 reference

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

21 January 2018

1 reference

Modeling human cortical development in vitro using induced pluripotent stem cells

21 January 2018

1 reference

A long, remarkable journey: tangential migration in the telencephalon.

21 January 2018

1 reference

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

21 January 2018

1 reference

Genome engineering of isogenic human ES cells to model autism disorders

21 January 2018

1 reference

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

21 January 2018

1 reference

Human pluripotent stem cells for disease modelling and drug screening

21 January 2018

1 reference

A transposable element inserted just 5′ to a Drosophila glue protein gene alters gene expression and chromatin structure

21 January 2018

1 reference

Contribution of SHANK3 mutations to autism spectrum disorder

21 January 2018

1 reference

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

21 January 2018

1 reference

Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

21 January 2018

1 reference

Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies

21 January 2018

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Standardization of human stem cell pluripotency using bioinformatics

21 January 2018

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Differentiation of serum-free embryoid bodies from human induced pluripotent stem cells into networks

21 January 2018

1 reference

A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors

21 January 2018

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Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.

21 January 2018

1 reference

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

21 January 2018

1 reference

Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism

21 January 2018

1 reference

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

21 January 2018

1 reference

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells

21 January 2018

1 reference

Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient

21 January 2018

1 reference

Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells

21 January 2018

1 reference

Imaging Voltage in Neurons

21 January 2018

1 reference

Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

21 January 2018

1 reference

Functional impact of global rare copy number variation in autism spectrum disorders

21 January 2018

1 reference

Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination

21 January 2018

1 reference

A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs).

21 January 2018

1 reference

Current status of drug screening and disease modelling in human pluripotent stem cells.

21 January 2018

1 reference

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery

21 January 2018

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CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

21 January 2018

1 reference

Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients.

21 January 2018

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Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes

21 January 2018

1 reference

Model of autism: increased ratio of excitation/inhibition in key neural systems

21 January 2018

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Protein interactome reveals converging molecular pathways among autism disorders

21 January 2018

1 reference

Next-generation regenerative medicine: organogenesis from stem cells in 3D culture

21 January 2018

1 reference

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

21 January 2018

1 reference

Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus

21 January 2018

1 reference

Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control

21 January 2018

1 reference

Autism and maternally derived aberrations of chromosome 15q.

21 January 2018

1 reference

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

1 reference

Brief report: prevalence of autism spectrum conditions in children aged 5-11 years in Cambridgeshire, UK.

21 January 2018

1 reference

Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders

21 January 2018

1 reference

Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

1 reference

Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes

21 January 2018

1 reference

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome

21 January 2018

1 reference

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

21 January 2018

1 reference

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

21 January 2018

1 reference

The NCI60 human tumour cell line anticancer drug screen

21 January 2018

1 reference

The anterior cingulate cortex in autism: heterogeneity of qualitative and quantitative cytoarchitectonic features suggests possible subgroups

21 January 2018

1 reference

A conditional knockout resource for the genome-wide study of mouse gene function

21 January 2018

1 reference

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

21 January 2018

1 reference

Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

21 January 2018

1 reference

Induced pluripotency: history, mechanisms, and applications

21 January 2018

1 reference

Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

21 January 2018

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Automated, scalable culture of human embryonic stem cells in feeder-free conditions.

21 January 2018

1 reference

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

21 January 2018

1 reference

Direct conversion of fibroblasts to functional neurons by defined factors

21 January 2018

1 reference

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

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Common genetic variants on 5p14.1 associate with autism spectrum disorders

21 January 2018

1 reference

Directed differentiation of telencephalic precursors from embryonic stem cells

21 January 2018

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Synaptic dysregulation in a human iPS cell model of mental disorders

21 January 2018

1 reference

Molecular characterisation of the 22q13 deletion syndrome supports the role of haploinsufficiency of SHANK3/PROSAP2 in the major neurological symptoms

21 January 2018

1 reference

iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease

21 January 2018

1 reference

Characterization of discrete subpopulations of progenitor cells in traumatic human extremity wounds

21 January 2018

1 reference

Concise review: a high-content screening approach to stem cell research and drug discovery

21 January 2018

1 reference

Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

21 January 2018

1 reference

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

21 January 2018

1 reference

Modeling hippocampal neurogenesis using human pluripotent stem cells

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

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High content screening: seeing is believing.

21 January 2018

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Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells

21 January 2018

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Rapid single-step induction of functional neurons from human pluripotent stem cells

21 January 2018

1 reference

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons.

21 January 2018

1 reference

Induction of human neuronal cells by defined transcription factors

21 January 2018

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10202

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

30 October 2021

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.CELL.2007.11.019

Identifiers

DOI

10.1002/AUR.1570

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4 September 2017

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