Unconventional screening approaches for antibiotic discovery (Q38534653)

3 September 2017

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title

Unconventional screening approaches for antibiotic discovery (English)

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3 September 2017

Maya A Farha

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3 September 2017

Eric D Brown

series ordinal

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3 September 2017

language of work or name

English

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publication date

22 June 2015

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Annals of the New York Academy of Sciences

3 September 2017

published in

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3 September 2017

volume

1354

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3 September 2017

page(s)

54-66

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Antibiotic resistance-the need for global solutions

3 September 2017

cites work

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https://api.crossref.org/works/10.1111%2FNYAS.12803

Challenges of antibacterial discovery

21 January 2018

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Chemical genomic approaches to study model microbes

21 January 2018

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Systems biology: a brief overview

21 January 2018

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A new approach to decoding life: systems biology

21 January 2018

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How were new medicines discovered?

21 January 2018

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Discovery research: the scientific challenge of finding new antibiotics

21 January 2018

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Finding the target after screening the phenotype

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12803

A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Discovery of novel cell wall-active compounds using P ywaC, a sensitive reporter of cell wall stress, in the model gram-positive bacterium Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Discovery of a small molecule that inhibits bacterial ribosome biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

An inhibitor of gram-negative bacterial virulence protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Discovery of FabH/FabF inhibitors from natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Recent advances and method development for drug target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Experimental and computational assessment of conditionally essential genes in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A fine scale phenotype-genotype virulence map of a bacterial pathogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Genetic requirements for mycobacterial survival during infection

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12803

Requirements for Pseudomonas aeruginosa acute burn and chronic surgical wound infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Targeting bacterial central metabolism for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Revisiting the host as a growth medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

The future of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A practical view of 'druggability'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Persister cells, dormancy and infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Tuberculosis - metabolism and respiration in the absence of growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Advances in the development of new tuberculosis drugs and treatment regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Targeting persisters for tuberculosis control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A New Approach for the Discovery of Antibiotics by Targeting Non-Multiplying Bacteria: A Novel Topical Antibiotic for Staphylococcal Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Rapid test for distinguishing membrane-active antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Screen for agents that induce autolysis in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of novel antimicrobials using a live-animal infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

High-throughput screen for novel antimicrobials using a whole animal infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

An in vivo platform for rapid high-throughput antitubercular drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Zebrafish-Based Small Molecule Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

The use of zebrafish to understand immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Host-pathogen interactions made transparent with the zebrafish model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Multicomponent therapeutics for networked systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Systems biology and combination therapy in the quest for clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Multi-target therapeutics: when the whole is greater than the sum of the parts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Strategies for optimizing combinations of molecularly targeted anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Systematic discovery of multicomponent therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A forward chemical screen identifies antibiotic adjuvants in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Mechanism-independent method for predicting response to multidrug combinations in bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Chemical combination effects predict connectivity in biological systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Predicting selective drug targets in cancer through metabolic networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

Prediction of drug combinations by integrating molecular and pharmacological data

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

A network inference method for large-scale unsupervised identification of novel drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12803

21 January 2018

Identifiers

DOI

10.1111/NYAS.12803

1 reference

3 September 2017

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