Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases. (Q38432023)

PubMed publication ID

28394608

3 September 2017

title

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases (English)

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13 May 2020

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author name string

Manishabrata Bhowmick

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13 May 2020

Dorota Tokmina-Roszyk

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13 May 2020

Lillian Onwuha-Ekpete

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13 May 2020

Kelli Harmon

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13 May 2020

Trista Robichaud

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13 May 2020

Rita Fuerst

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13 May 2020

Roma Stawikowska

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13 May 2020

Bjorn Steffensen

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13 May 2020

Hector R Wong

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13 May 2020

language of work or name

English

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publication date

10 April 2017

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PubMed publication ID

28394608

Journal of Medicinal Chemistry

3 September 2017

published in

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13 May 2020

volume

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issue

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13 May 2020

page(s)

3814-3827

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A hyperstable collagen mimic

13 May 2020

cites work

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Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis

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Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9).

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Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.

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Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor

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Design and therapeutic application of matrix metalloproteinase inhibitors

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A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases

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New functions for the matrix metalloproteinases in cancer progression

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Strategies for MMP inhibition in cancer: innovations for the post-trial era.

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Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9

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Asymmetric Hydrogenations for the Synthesis of Boc-Protected 4-Alkylprolinols and Prolines

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TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

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Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody

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12 December 2020

Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme

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12 December 2020

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

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12 December 2020

Recent developments in the design of specific Matrix Metalloproteinase inhibitors aided by structural and computational studies

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12 December 2020

Structural basis for the highly selective inhibition of MMP-13.

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12 December 2020

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

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12 December 2020

Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs

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12 December 2020

Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

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Towards third generation matrix metalloproteinase inhibitors for cancer therapy

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Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis

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Matrix metalloproteinase dependent and independent collagen degradation

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12 December 2020

Reciprocity of steric and stereoelectronic effects in the collagen triple helix

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12 December 2020

Potent, selective pyrimidinetrione-based inhibitors of MMP-13

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12 December 2020

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

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12 December 2020

A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains

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12 December 2020

Matrix metalloproteinases as valid clinical targets

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12 December 2020

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

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12 December 2020

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

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12 December 2020

Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains.

1 reference

12 December 2020

Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators

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12 December 2020

Inhibitor fingerprinting of matrix metalloproteases using a combinatorial peptide hydroxamate library

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12 December 2020

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

1 reference

12 December 2020

Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors

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12 December 2020

Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors

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12 December 2020

Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

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12 December 2020

IL-10: the master regulator of immunity to infection

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12 December 2020

Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition

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12 December 2020

Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold

1 reference

12 December 2020

Elevated matrix metalloproteinase-9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques

1 reference

12 December 2020

Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.

1 reference

12 December 2020

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

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12 December 2020

Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors

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12 December 2020

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

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12 December 2020

Stereoelectronic and steric effects in side chains preorganize a protein main chain

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12 December 2020

Efficient synthesis of Fmoc-protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors

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12 December 2020

SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability

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12 December 2020

Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway

1 reference

12 December 2020

Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

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12 December 2020

Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities

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12 December 2020

A novel role for matrix metalloproteinase-8 in sepsis

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12 December 2020

Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis

1 reference

12 December 2020

Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain

1 reference

12 December 2020

Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis

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12 December 2020

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

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12 December 2020

IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis

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12 December 2020

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12 December 2020

Mouse models of multiple sclerosis: experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease

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12 December 2020

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

1 reference

12 December 2020

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems

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12 December 2020

Interstitial collagen catabolism

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12 December 2020

Potential of collagen-like triple helical peptides as drug carriers: Their in vivo distribution, metabolism, and excretion profiles in rodents

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12 December 2020

Collagen-like cell-penetrating peptides.

1 reference

12 December 2020

Matrix metalloproteinases and their pathological upregulation in multiple sclerosis: an overview

1 reference

12 December 2020

Stabilization of collagen-model, triple-helical peptides for in vitro and in vivo applications

1 reference

12 December 2020

The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.

1 reference

12 December 2020

Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

1 reference

12 December 2020

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

1 reference

12 December 2020

Myelin oligodendrocyte glycoprotein (MOG35-55) induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice

1 reference

12 December 2020

Network analyses reveal pervasive functional regulation between proteases in the human protease web

1 reference

12 December 2020

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

1 reference

12 December 2020

Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach

1 reference

12 December 2020

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

1 reference

12 December 2020

Phosphinic peptides as potent inhibitors of zinc-metalloproteases

1 reference

12 December 2020

Is there new hope for therapeutic matrix metalloproteinase inhibition?

1 reference

12 December 2020

Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody

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12 December 2020

Peptide internalization enabled by folding: triple helical cell-penetrating peptides

1 reference

12 December 2020

TIMP-1 resistant matrix metalloproteinase-9 is the predominant serum active isoform associated with MRI activity in patients with multiple sclerosis

1 reference

12 December 2020

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

1 reference

12 December 2020

Matrix metalloproteinase inhibition by heterotrimeric triple-helical Peptide transition state analogues

1 reference

12 December 2020

Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates

1 reference

12 December 2020

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

1 reference

12 December 2020

Fusion Peptides CPU1 and CPU2 Inhibit Matrix Metalloproteinases and Protect Mice from Endotoxin Shock Within a Strict Time Window

1 reference

12 December 2020

Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis

1 reference

12 December 2020

Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13.

1 reference

12 December 2020

Fecal Excretion of Orally Administered Collagen-Like Peptides in Rats: Contribution of the Triple-Helical Conformation to Their Stability

1 reference

12 December 2020

Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

1 reference

12 December 2020

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

1 reference

12 December 2020

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis

1 reference

12 December 2020

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.

1 reference

12 December 2020

Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients

1 reference

12 December 2020

Marine pharmacology: therapeutic targeting of matrix metalloproteinases in neuroinflammation

1 reference

12 December 2020

Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier.

1 reference

12 December 2020

Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia.

1 reference

12 December 2020

Monoclonal Antibodies Specific for Natural Human Neutrophil Gelatinase B Used for Affinity Purification, Quantitation by Two-Site ELISA and Inhibition of Enzymatic Activity

1 reference

12 December 2020

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury

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12 December 2020

Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors

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12 December 2020

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12 December 2020

10.1021/ACS.JMEDCHEM.7B00018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6413923&resulttype=core&format=json

13 May 2020

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13 May 2020

PubMed publication ID

28394608

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6413923&resulttype=core&format=json