Atoh1 gene therapy in the cochlea for hair cell regeneration (Q38342851)

2 September 2017

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title

Atoh1 gene therapy in the cochlea for hair cell regeneration (English)

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2 September 2017

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Patrick J Atkinson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

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publication date

3 February 2015

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Expert Opinion on Biological Therapy

2 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

417-430

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

Factors Affecting Auditory Performance of Postlinguistically Deaf Adults Using Cochlear Implants

1 June 2020

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Non-sensory cells in the deafened organ of Corti: approaches for repair

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Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea

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Math1: an essential gene for the generation of inner ear hair cells

21 January 2018

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Math1 regulates development of the sensory epithelium in the mammalian cochlea

21 January 2018

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β-Catenin is required for hair-cell differentiation in the cochlea

21 January 2018

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Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer

21 January 2018

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The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival

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Notch signalling pathway mediates hair cell development in mammalian cochlea

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Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas

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Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea

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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

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Regulation of cell fate in the sensory epithelia of the inner ear.

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Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears

21 January 2018

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A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability

21 January 2018

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Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.

21 January 2018

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The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.

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Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

21 January 2018

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Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration

21 January 2018

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Regeneration of sensory hair cells after acoustic trauma

21 January 2018

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Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs

21 January 2018

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Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells

21 January 2018

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Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle.

21 January 2018

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Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea

21 January 2018

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Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

21 January 2018

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Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea

21 January 2018

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alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

21 January 2018

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Prestin is the motor protein of cochlear outer hair cells

21 January 2018

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Oncomodulin Is Expressed Exclusively by Outer Hair Cells in the Organ of Corti

21 January 2018

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In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression

21 January 2018

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Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression

21 January 2018

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Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs

21 January 2018

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Gene therapy clinical trials worldwide to 2012 - an update.

21 January 2018

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

21 January 2018

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Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea

21 January 2018

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Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae

21 January 2018

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The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice

21 January 2018

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Cochlear gene transfer: round window versus cochleostomy inoculation

21 January 2018

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A surgical approach appropriate for targeted cochlear gene therapy in the mouse

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult

21 January 2018

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Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Atoh1 induces auditory hair cell recovery in mice after ototoxic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Response of the flat cochlear epithelium to forced expression of Atoh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2015.1009889

Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity

21 January 2018

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21 January 2018

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Selective atonal gene delivery improves balance function in a mouse model of vestibular disease

21 January 2018

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Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo

21 January 2018

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An independent construct for conditional expression of atonal homolog-1.

21 January 2018

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Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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10.1517/14712598.2015.1009889

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25648190%20AND%20SRC:MED&resulttype=core&format=json