Therapeutic modulation of Notch signalling--are we there yet? (Q38208211)

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

21 January 2018

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

21 January 2018

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

21 January 2018

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Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis

21 January 2018

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Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

21 January 2018

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Mutated MESP2 causes spondylocostal dysostosis in humans

21 January 2018

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Notch signaling: simplicity in design, versatility in function

21 January 2018

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The Notch signalling system: recent insights into the complexity of a conserved pathway

21 January 2018

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Targeting Notch signaling for cancer therapeutic intervention

21 January 2018

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Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

21 January 2018

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Notch signalling: a simple pathway becomes complex

21 January 2018

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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

21 January 2018

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Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

21 January 2018

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Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways

21 January 2018

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

21 January 2018

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The dawn of developmental signaling in the metazoa

21 January 2018

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The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

21 January 2018

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Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

21 January 2018

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A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands

21 January 2018

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Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

21 January 2018

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Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

21 January 2018

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Fringe modulates Notch-ligand interactions.

21 January 2018

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Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

21 January 2018

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Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

21 January 2018

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Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ.

21 January 2018

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Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

21 January 2018

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Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

21 January 2018

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Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

21 January 2018

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Delta-like ligand 4-notch blockade and tumor radiation response

21 January 2018

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The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.

21 January 2018

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A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

21 January 2018

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Fc-fusion proteins: new developments and future perspectives.

21 January 2018

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Induction of notch signaling by immobilization of jagged-1 on self-assembled monolayers.

21 January 2018

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

21 January 2018

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Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype

21 January 2018

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The non-transmembrane form of Delta1, but not of Jagged1, induces normal migratory behavior accompanied by fibroblast growth factor receptor 1-dependent transformation

21 January 2018

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The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

21 January 2018

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Notch activation inhibits AML growth and survival: a potential therapeutic approach

21 January 2018

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Notch signalling regulates stem cell numbers in vitro and in vivo

21 January 2018

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Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

21 January 2018

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The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface

21 January 2018

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Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

21 January 2018

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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

21 January 2018

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

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Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

21 January 2018

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Ligand-induced signaling in the absence of furin processing of Notch1.

21 January 2018

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Furin cleavage is not a requirement for Drosophila Notch function

21 January 2018

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The biology and therapeutic targeting of the proprotein convertases

21 January 2018

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Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

21 January 2018

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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

21 January 2018

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Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways

21 January 2018

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Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats

21 January 2018

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Fringe is a glycosyltransferase that modifies Notch

21 January 2018

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Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

21 January 2018

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Defining single molecular forces required to activate integrin and notch signaling

21 January 2018

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DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

21 January 2018

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Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

21 January 2018

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

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Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

21 January 2018

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Proteolytic cleavage of Notch: "HIT and RUN".

21 January 2018

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Translocation of the Cytoplasmic Domain of ADAM13 to the Nucleus Is Essential for Calpain8-a Expression and Cranial Neural Crest Cell Migration

21 January 2018

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ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

21 January 2018

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Therapeutic antibody targeting of individual Notch receptors

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

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γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane

21 January 2018

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Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

21 January 2018

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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

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Secretion of the Notch-1 Abeta-like peptide during Notch signaling

21 January 2018

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Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers

21 January 2018

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Dynamic binding of RBPJ is determined by Notch signaling status.

21 January 2018

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Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

21 January 2018

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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

21 January 2018

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Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

21 January 2018

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

21 January 2018

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The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

21 January 2018

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Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

21 January 2018

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Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo

21 January 2018

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The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

21 January 2018

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Transcriptional mechanisms by the coregulator MAML1.

21 January 2018

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Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.

21 January 2018

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Direct inhibition of the NOTCH transcription factor complex

21 January 2018

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Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2.

21 January 2018

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Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.

21 January 2018

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Notch-independent functions of CSL.

21 January 2018

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Glycogen synthase kinase-3beta modulates notch signaling and stability

21 January 2018

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

21 January 2018

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Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

21 January 2018

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The multiple facets of ubiquitination in the regulation of notch signaling pathway.

21 January 2018

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

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Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

21 January 2018

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The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

21 January 2018

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

21 January 2018

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

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Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

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Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

21 January 2018

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A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.

21 January 2018

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Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila.

21 January 2018

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Notch synergizes with axin to regulate the activity of armadillo in Drosophila.

21 January 2018

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Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity

21 January 2018

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Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

21 January 2018

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Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors

21 January 2018

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Interaction between Wingless and Notch signaling pathways mediated by dishevelled

21 January 2018

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Wingless modulates the ligand independent traffic of Notch through Dishevelled.

21 January 2018

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Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

21 January 2018

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Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.

21 January 2018

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

21 January 2018

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Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

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Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

21 January 2018

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Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?

21 January 2018

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Non-canonical Notch signaling: emerging role and mechanism

21 January 2018

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Canonical and non-canonical Notch ligands

21 January 2018

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Notch signaling and development of the hematopoietic system.

21 January 2018

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Notch signaling in lung development and disease

21 January 2018

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The role of Notch signaling in kidney development and disease

21 January 2018

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Ligand-dependent Notch signaling in vascular formation

21 January 2018

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Notch signaling and the developing inner ear.

21 January 2018

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Notch signaling and the developing hair follicle

21 January 2018

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Notch signaling and the developing skeleton.

21 January 2018

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A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

21 January 2018

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

21 January 2018

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Notch pathway activation targets AML-initiating cell homeostasis and differentiation

21 January 2018

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Notch signalling via RBP-J promotes myeloid differentiation.

21 January 2018

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Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines

21 January 2018

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In vivo mapping of notch pathway activity in normal and stress hematopoiesis

21 January 2018

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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

21 January 2018

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Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway.

21 January 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

21 January 2018

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Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa

21 January 2018

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Intracellular forms of human NOTCH1 functionally activate essential Epstein-Barr virus major latent promoters in the Burkitt's lymphoma BJAB cell line but repress these promoters in Jurkat cells

21 January 2018

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Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2.

21 January 2018

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Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells

21 January 2018

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Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

21 January 2018

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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

21 January 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

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Notch signaling in acute promyelocytic leukemia

21 January 2018

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Notch2 and Notch3 function together to regulate vascular smooth muscle development.

21 January 2018

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

21 January 2018

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Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

21 January 2018

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

21 January 2018

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

21 January 2018

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sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation

21 January 2018

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Gridlock signalling pathway fashions the first embryonic artery

21 January 2018

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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

21 January 2018

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Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.

21 January 2018

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Novel MIR143-NOTCH fusions in benign and malignant glomus tumors

21 January 2018

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Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients

21 January 2018

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Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL

21 January 2018

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Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

21 January 2018

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Notch3 signaling promotes the development of pulmonary arterial hypertension

21 January 2018

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CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension

21 January 2018

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Coordinating tissue interactions: Notch signaling in cardiac development and disease

21 January 2018

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

21 January 2018

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Notch signaling is essential for ventricular chamber development

21 January 2018

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Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves

21 January 2018

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Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

21 January 2018

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Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse

21 January 2018

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Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

21 January 2018

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Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways

21 January 2018

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Mutations in NOTCH1 cause aortic valve disease

21 January 2018

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Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve

21 January 2018

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Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

21 January 2018

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Notch1 represses osteogenic pathways in aortic valve cells

21 January 2018

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Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL

21 January 2018

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Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

21 January 2018

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Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

21 January 2018

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Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

21 January 2018

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Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

21 January 2018

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Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

21 January 2018

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Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

21 January 2018

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Canonical notch signaling functions as a commitment switch in the epidermal lineage

21 January 2018

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Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

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Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity

21 January 2018

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Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin

21 January 2018

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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

21 January 2018

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The epigenetic landscape of oral squamous cell carcinoma

21 January 2018

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The pathological significance of Notch1 in oral squamous cell carcinoma

21 January 2018

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Vertebrate segmentation: from cyclic gene networks to scoliosis

21 January 2018

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A complex oscillating network of signaling genes underlies the mouse segmentation clock.

21 January 2018

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21 January 2018

Somites without a clock.

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Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

21 January 2018

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Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome

21 January 2018

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A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

21 January 2018

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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

21 January 2018

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Hair cells without supporting cells: further studies in the ear of the zebrafish mind bomb mutant

21 January 2018

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Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

21 January 2018

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The Notch ligand Jagged1 is required for inner ear sensory development.

21 January 2018

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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti

21 January 2018

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Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome

21 January 2018

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Robust cellular reprogramming occurs spontaneously during liver regeneration.

21 January 2018

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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

21 January 2018

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A critical role for notch signaling in the formation of cholangiocellular carcinomas

21 January 2018

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Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice

21 January 2018

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Transcriptome analysis of the normal human mammary cell commitment and differentiation process

21 January 2018

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Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

21 January 2018

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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

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Aberrant activation of notch signaling in human breast cancer

21 January 2018

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Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

21 January 2018

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Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells

21 January 2018

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Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.

21 January 2018

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Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages

21 January 2018

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Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth

21 January 2018

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Whole exome sequencing of adenoid cystic carcinoma

21 January 2018

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

21 January 2018

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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo

21 January 2018

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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

21 January 2018

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

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Inhibition of tumor angiogenesis and tumor growth by the DSL domain of human Delta-like 1 targeted to vascular endothelial cells

21 January 2018

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A phase 3 trial of semagacestat for treatment of Alzheimer's disease

21 January 2018

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Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors

21 January 2018

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Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

21 January 2018

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Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

21 January 2018

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A phase II study of RO4929097 in metastatic colorectal cancer

21 January 2018

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Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells

21 January 2018

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gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

21 January 2018

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Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines

21 January 2018

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A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503).

21 January 2018

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A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

21 January 2018

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A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

21 January 2018

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Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma

21 January 2018

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Hair cell generation by notch inhibition in the adult mammalian cristae.

21 January 2018

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Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.

21 January 2018

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Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited

21 January 2018

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Treatment of pulmonary arterial hypertension with targeted therapies

21 January 2018

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Blockade of individual Notch ligands and receptors controls graft-versus-host disease

21 January 2018

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Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats

21 January 2018

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Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

21 January 2018

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

21 January 2018

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Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

21 January 2018

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Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status

21 January 2018

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Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

21 January 2018

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Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells

21 January 2018

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PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

21 January 2018

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Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin

21 January 2018

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Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer

21 January 2018

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Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model

21 January 2018

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Mechanistic insights into Notch receptor signaling from structural and biochemical studies

21 January 2018

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PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor

21 January 2018

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

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Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

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Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

21 January 2018

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γ-Secretase as a target for Alzheimer's disease

21 January 2018

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Notch and disease: a growing field

21 January 2018

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NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients

21 January 2018

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Molecular mechanisms of bile duct development

21 January 2018

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Notch signaling and the developing skin epidermis

21 January 2018

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Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis

21 January 2018

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Mutations in PDGFRB and NOTCH3 are the first genetic causes identified for autosomal dominant infantile myofibromatosis

21 January 2018

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Activation of the NOTCH pathway in head and neck cancer

21 January 2018

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Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

21 January 2018

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

21 January 2018

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The mutational landscape of head and neck squamous cell carcinoma

21 January 2018

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The role of Notch in patterning the human vertebral column

21 January 2018

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Notch signaling and bone remodeling

21 January 2018

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Notch signalling in smooth muscle cells during development and disease

21 January 2018

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Notch as a hub for signaling in angiogenesis.

21 January 2018

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Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

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Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells

21 January 2018

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Orientation-regulated immobilization of Jagged1 on glass substrates for ex vivo proliferation of a bone marrow cell population containing hematopoietic stem cells

31 March 2020

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Notch-mediated restoration of regenerative potential to aged muscle

31 March 2020

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Control of Notch-ligand endocytosis by ligand-receptor interaction

31 March 2020

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

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PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

31 March 2020

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

31 March 2020

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Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting

31 March 2020

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Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-κB activity

31 March 2020

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Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

31 March 2020

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Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors

31 March 2020

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Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis

31 March 2020

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12 December 2020

Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis

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12 December 2020

Notch inhibitor: a promising carcinoma radiosensitizer.

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12 December 2020

Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development.

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12 December 2020

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

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12 December 2020

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

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12 December 2020

notch2, notch4 gene polymorphisms in psoriasis vulgaris

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12 December 2020

Disruption of the mouse RBP-J kappa gene results in early embryonic death

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12 December 2020

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development

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12 December 2020

The Notch pathway in hematopoietic stem cells.

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12 December 2020

Notch signaling is essential for vascular morphogenesis in mice

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12 December 2020

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

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12 December 2020

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

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12 December 2020

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation

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12 December 2020

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

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12 December 2020

Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant

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12 December 2020

Rules for the production of sensory cells

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12 December 2020

The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer.

1 reference

12 December 2020