The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases (Q38162038)

30 August 2017

title

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases (English)

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30 August 2017

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6 June 2020

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6 June 2020

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6 June 2020

A Tefferi

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6 June 2020

F Fuks

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publication date

13 November 2013

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30 August 2017

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volume

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issue

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page(s)

485-496

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Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma

6 June 2020

cites work

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12 December 2020

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

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12 December 2020

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

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12 December 2020

Isocitrate dehydrogenase mutations in leukemia

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12 December 2020

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

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12 December 2020

Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia

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12 December 2020

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

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12 December 2020

Clinical effect of point mutations in myelodysplastic syndromes

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12 December 2020

Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

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12 December 2020

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

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12 December 2020

In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells

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12 December 2020

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

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12 December 2020

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

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12 December 2020

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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12 December 2020

Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond

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12 December 2020

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

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12 December 2020

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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12 December 2020

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

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12 December 2020

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

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12 December 2020

Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells.

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12 December 2020

Acquired mutations in TET2 are common in myelodysplastic syndromes

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12 December 2020

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

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12 December 2020

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance

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12 December 2020

TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis

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12 December 2020

Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

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12 December 2020

Clinical and biological implications of driver mutations in myelodysplastic syndromes

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12 December 2020

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

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12 December 2020

Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia

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12 December 2020

Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors

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12 December 2020

Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis

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12 December 2020

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

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12 December 2020

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.

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12 December 2020

Mutation in TET2 in myeloid cancers

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12 December 2020

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

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12 December 2020

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

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12 December 2020

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

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12 December 2020

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

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12 December 2020

Mutations and prognosis in primary myelofibrosis

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12 December 2020

Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells

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12 December 2020

DNA methylation: TET proteins-guardians of CpG islands?

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12 December 2020

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

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12 December 2020

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

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12 December 2020

The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.

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12 December 2020

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes

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12 December 2020

Influence of metabolism on epigenetics and disease

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12 December 2020

Landscape of TET2 mutations in acute myeloid leukemia

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12 December 2020

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

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12 December 2020

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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12 December 2020

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

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12 December 2020

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

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12 December 2020

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

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12 December 2020

Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.

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12 December 2020

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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12 December 2020

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

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12 December 2020

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

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12 December 2020

Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins

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12 December 2020

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

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12 December 2020

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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12 December 2020

Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.

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12 December 2020

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

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12 December 2020

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

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12 December 2020

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

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12 December 2020

Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.

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12 December 2020

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

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12 December 2020

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

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12 December 2020

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

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12 December 2020

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

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12 December 2020

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

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12 December 2020

TET2 and TP53 mutations are frequently observed in blastic plasmacytoid dendritic cell neoplasm

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12 December 2020

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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12 December 2020

Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling.

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12 December 2020

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

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12 December 2020

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

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12 December 2020

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

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12 December 2020

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions.

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12 December 2020

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis

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12 December 2020

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

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12 December 2020

DNA Demethylation Dynamics

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12 December 2020

Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

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12 December 2020

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

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12 December 2020

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial.

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12 December 2020

Somatic alterations contributing to metastasis of a castration-resistant prostate cancer

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12 December 2020

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

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12 December 2020

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

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12 December 2020

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

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12 December 2020

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

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12 December 2020

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.

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12 December 2020

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

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12 December 2020

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

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12 December 2020

TET2 mutations in childhood leukemia

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12 December 2020

Clonal architecture of chronic myelomonocytic leukemias

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12 December 2020

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

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12 December 2020

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

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12 December 2020

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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12 December 2020

An evolutionary perspective on chronic myelomonocytic leukemia.

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12 December 2020

Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

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12 December 2020

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

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12 December 2020

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

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12 December 2020

TET2 and DNMT3A mutations in human T-cell lymphoma

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12 December 2020

Mutation analysis of TET2, IDH1, IDH2 and ASXL1 in chronic myeloid leukemia

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12 December 2020

MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

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12 December 2020

IDH mutation impairs histone demethylation and results in a block to cell differentiation

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12 December 2020

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

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12 December 2020

The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

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12 December 2020

Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase

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12 December 2020

Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

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12 December 2020

TET2 promotes histone O-GlcNAcylation during gene transcription

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12 December 2020

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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12 December 2020

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

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12 December 2020

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

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12 December 2020

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

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12 December 2020

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

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12 December 2020

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

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12 December 2020

Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine

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12 December 2020

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

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12 December 2020

Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion

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12 December 2020

TET2 mutations in secondary acute myeloid leukemias: a French retrospective study

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12 December 2020

Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency

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12 December 2020

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

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12 December 2020

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

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12 December 2020