Tumor metastasis: moving new biological insights into the clinic (Q38160740)

Molecular portraits of human breast tumours

21 January 2018

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A gene-expression signature as a predictor of survival in breast cancer

21 January 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

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Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity

21 January 2018

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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

21 January 2018

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BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

21 January 2018

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Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.

21 January 2018

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Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b

21 January 2018

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Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 January 2018

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

21 January 2018

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HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab.

21 January 2018

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Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer.

21 January 2018

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Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

21 January 2018

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Cancer metastasis: building a framework

21 January 2018

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Dissemination and growth of cancer cells in metastatic sites

21 January 2018

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Tumour-cell invasion and migration: diversity and escape mechanisms

21 January 2018

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Classifying collective cancer cell invasion

21 January 2018

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Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis

21 January 2018

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Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

21 January 2018

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Epithelial-mesenchymal transitions in development and disease

21 January 2018

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Control of metastatic progression by microRNA regulatory networks

21 January 2018

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The epigenetics of epithelial-mesenchymal plasticity in cancer

21 January 2018

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Regulatory networks defining EMT during cancer initiation and progression

21 January 2018

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Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links

21 January 2018

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

21 January 2018

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Plasticity of disseminating cancer cells in patients with epithelial malignancies

21 January 2018

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Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition

21 January 2018

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Matrix metalloproteinases: regulators of the tumor microenvironment

21 January 2018

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Heritability of mammographic density, a risk factor for breast cancer

21 January 2018

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Collagen density promotes mammary tumor initiation and progression

21 January 2018

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

21 January 2018

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LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

21 January 2018

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Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

21 January 2018

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RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

21 January 2018

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The extracellular matrix: a dynamic niche in cancer progression

21 January 2018

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Tumor angiogenesis: molecular pathways and therapeutic targets

21 January 2018

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Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling

21 January 2018

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Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

21 January 2018

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Tumor metastasis: molecular insights and evolving paradigms

21 January 2018

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Genes that mediate breast cancer metastasis to lung

21 January 2018

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TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

21 January 2018

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Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

21 January 2018

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Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

21 January 2018

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Genes that mediate breast cancer metastasis to the brain

21 January 2018

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Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

21 January 2018

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Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.

21 January 2018

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The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications

21 January 2018

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Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

21 January 2018

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Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies

21 January 2018

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Dissecting the metastatic cascade

21 January 2018

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Models, mechanisms and clinical evidence for cancer dormancy

21 January 2018

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The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions

21 January 2018

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Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

21 January 2018

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Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

21 January 2018

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Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment

21 January 2018

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Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

21 January 2018

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Tumor cell dormancy induced by p38SAPK and ER-stress signaling: an adaptive advantage for metastatic cells?

21 January 2018

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ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease

21 January 2018

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The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites

21 January 2018

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A multigenic program mediating breast cancer metastasis to bone

21 January 2018

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Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

21 January 2018

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Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes.

21 January 2018

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VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors

21 January 2018

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Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

21 January 2018

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Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

21 January 2018

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Accessories to the crime: functions of cells recruited to the tumor microenvironment

21 January 2018

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Microenvironmental regulation of tumor progression and metastasis

21 January 2018

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Stromal gene expression predicts clinical outcome in breast cancer

21 January 2018

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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

21 January 2018

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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

21 January 2018

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Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion

21 January 2018

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

21 January 2018

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

21 January 2018

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Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.

21 January 2018

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Hypoxia and hypoxia-inducible factors: master regulators of metastasis

21 January 2018

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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

21 January 2018

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EMT and dissemination precede pancreatic tumor formation

21 January 2018

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Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success

21 January 2018

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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

21 January 2018

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Molecular origins of cancer: Molecular basis of colorectal cancer

21 January 2018

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

21 January 2018

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

21 January 2018

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Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

21 January 2018

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The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

21 January 2018

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The metastatic niche: adapting the foreign soil

21 January 2018

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Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.

21 January 2018

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Bone-marrow haematopoietic-stem-cell niches

21 January 2018

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The perivascular niche regulates breast tumour dormancy.

21 January 2018

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Real-time imaging reveals the single steps of brain metastasis formation

21 January 2018

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Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

21 January 2018

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

21 January 2018

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Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

21 January 2018

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Suppression of lung adenocarcinoma progression by Nkx2-1

21 January 2018

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Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma

21 January 2018

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Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis

21 January 2018

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GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

21 January 2018

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GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

21 January 2018

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Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

21 January 2018

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Slug and Sox9 cooperatively determine the mammary stem cell state

21 January 2018

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WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis

21 January 2018

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Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

21 January 2018

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

21 January 2018

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ID genes mediate tumor reinitiation during breast cancer lung metastasis

21 January 2018

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Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

21 January 2018

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Interactions between cancer stem cells and their niche govern metastatic colonization

21 January 2018

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VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

21 January 2018

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Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture

21 January 2018

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A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

21 January 2018

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Epigenetic reprogramming in cancer

21 January 2018

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Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration.

21 January 2018

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Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming

21 January 2018

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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

21 January 2018

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Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

21 January 2018

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Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

21 January 2018

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Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

21 January 2018

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Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth

21 January 2018

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Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

21 January 2018

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Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.

21 January 2018

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Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells

21 January 2018

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The identification and characterization of breast cancer CTCs competent for brain metastasis

21 January 2018

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A perspective on cancer cell metastasis

21 January 2018

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The epithelial cell default‐phenotype hypothesis and its implications for cancer

21 January 2018

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Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

21 January 2018

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Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin

21 January 2018

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Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition.

21 January 2018

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Systemic spread is an early step in breast cancer

21 January 2018

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Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma.

21 January 2018

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Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast

21 January 2018

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Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis

21 January 2018

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Pancreatic cancer genomics: insights and opportunities for clinical translation

21 January 2018

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Tumor self-seeding by circulating cancer cells

21 January 2018

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A pooled analysis of bone marrow micrometastasis in breast cancer

21 January 2018

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Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial

21 January 2018

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Endocrine therapy plus zoledronic acid in premenopausal breast cancer.

21 January 2018

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Clinical implications of cancer self-seeding

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor

21 January 2018

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Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 January 2018

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Clonal selection drives genetic divergence of metastatic medulloblastoma

21 January 2018

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Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

21 January 2018

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

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Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing

21 January 2018

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

21 January 2018

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

21 January 2018

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Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment

21 January 2018

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Genome-wide detection of single-nucleotide and copy-number variations of a single human cell

21 January 2018

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Tumour evolution inferred by single-cell sequencing

21 January 2018

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Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients

21 January 2018

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Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer.

21 January 2018

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From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression

21 January 2018

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

21 January 2018

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MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer

21 January 2018

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A CXCL1 paracrine network links cancer chemoresistance and metastasis

21 January 2018

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DNA damage-mediated induction of a chemoresistant niche

21 January 2018

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

21 January 2018

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Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases

21 January 2018

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An autoimmune-mediated strategy for prophylactic breast cancer vaccination

21 January 2018

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Detection, clinical relevance and specific biological properties of disseminating tumour cells

21 January 2018

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Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.

21 January 2018

1 reference

Sensitivity to the aromatase inhibitor letrozole is prolonged after a "break" in treatment

21 January 2018

1 reference

Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study

21 January 2018

1 reference

Cerebral hemorrhage, warfarin, and intravenous tPA: the real risk is not treating

21 January 2018

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Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited

21 January 2018

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Metastasis awakening: the challenges of targeting minimal residual cancer

21 January 2018

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Detection of mutations in EGFR in circulating lung-cancer cells

21 January 2018

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Quantitative high-resolution genomic analysis of single cancer cells

21 January 2018

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Latent bone metastasis in breast cancer tied to Src-dependent survival signals

21 January 2018

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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

21 January 2018

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Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.

21 January 2018

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The role of metastasis suppressor genes in metastatic dormancy

21 January 2018

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Thinking outside the box: Using metastasis suppressors as molecular tools

21 January 2018

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Metastasis suppressors and the tumor microenvironment

21 January 2018

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Bisphosphonates in the prevention of disease recurrence: current results and ongoing trials.

21 January 2018

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Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis

21 January 2018

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TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases

21 January 2018

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Clinical opportunities and challenges in targeting tumour dormancy

21 January 2018

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Controversies in clinical cancer dormancy

21 January 2018

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Tumor dormancy and immunoescape.

21 January 2018

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Sipuleucel-T immunotherapy for castration-resistant prostate cancer

21 January 2018

1 reference

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

Ipilimumab plus dacarbazine for previously untreated metastatic melanoma

21 January 2018

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Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases

21 January 2018

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Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs

21 January 2018

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Tracking tumor resistance using 'liquid biopsies'.

21 January 2018

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A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

21 January 2018

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21 January 2018

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

21 January 2018

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Intermittent androgen blockade should be regarded as standard therapy in prostate cancer.

21 January 2018

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Intermittent versus continuous androgen deprivation therapy in advanced prostate cancer

21 January 2018

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Metronomic chemotherapy: new rationale for new directions

21 January 2018

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Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice

21 January 2018

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Metastasis: from dissemination to organ-specific colonization

21 January 2018

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Capture of viable circulating tumor cells in the liver of colorectal cancer patients.

21 January 2018

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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

21 January 2018

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Analysis of circulating tumor DNA to monitor metastatic breast cancer

21 January 2018

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Considerations in the development of circulating tumor cell technology for clinical use

21 January 2018

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Clinical usefulness of bone markers in prostate cancer with bone metastasis

21 January 2018

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Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

21 January 2018

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Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

21 January 2018

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Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer

21 January 2018

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Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

21 January 2018

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In vivo imaging of glucose uptake and metabolism in tumors

21 January 2018

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Imaging oxygenation of human tumours

21 January 2018

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Targeted in vivo imaging of angiogenesis: present status and perspectives

21 January 2018

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Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

21 January 2018

1 reference

(18)F-FDG PET/CT for monitoring treatment responses to the epidermal growth factor receptor inhibitor erlotinib

21 January 2018

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Is cancer a disease of self-seeding?

21 January 2018

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A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

21 January 2018

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Cancer theory faces doubts

21 January 2018

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Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

21 January 2018

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Perspective: The right trials

21 January 2018

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Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse

21 January 2018

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12 December 2020

Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992

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12 December 2020

Metastatic patterns of cancers: results from a large autopsy study

1 reference

12 December 2020

ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients

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12 December 2020

Transmission of glioblastoma multiforme after bilateral lung transplantation

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12 December 2020

To differentiate or not--routes towards metastasis

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12 December 2020

Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients

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12 December 2020

Oligometastases revisited

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12 December 2020

Metastatic inefficiency: the scientific basis for resection of liver metastases from colorectal cancer

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12 December 2020

Tumor-vascular interactions and tumor dormancy

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12 December 2020

TEACH: Tykerb evaluation after chemotherapy

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12 December 2020

Host genetics influence tumour metastasis

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12 December 2020

Multilayer control of the EMT master regulators

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12 December 2020

Denosumab an option for patients with bone metastasis from breast cancer

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12 December 2020

Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ

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12 December 2020

Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.

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12 December 2020

Cell lineage specification in tumor progression and metastasis

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12 December 2020

Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis

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12 December 2020

Tumor targeting by an aptamer

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12 December 2020

Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer: a randomized trial

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12 December 2020

Three-Dimensional Imaging and Quantification of Both Solitary Cells and Metastases in Whole Mouse Liver by Magnetic Resonance Imaging

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12 December 2020

Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer

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12 December 2020

Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer

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12 December 2020

Circulating tumor cells in patients with breast cancer dormancy

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12 December 2020

Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis

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12 December 2020

KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.

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7 January 2021