Leptin-activity blockers: development and potential use in experimental biology and medicine (Q38151768)

29 August 2017

title

Leptin-activity blockers: development and potential use in experimental biology and medicine (English)

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29 August 2017

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Arieh Gertler

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29 August 2017

Gili Solomon

series ordinal

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29 August 2017

publication date

22 April 2013

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Canadian Journal of Physiology and Pharmacology

29 August 2017

published in

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

873-882

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Early postnatal leptin blockage leads to a long-term leptin resistance and susceptibility to diet-induced obesity in rats.

29 August 2017

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Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis

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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

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Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function.

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Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

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Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

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Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells

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A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells

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Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

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Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling

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Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.

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Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor

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Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist

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Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

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Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses

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Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process

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Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists

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21 January 2018

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Leptin: a pivotal mediator of intestinal inflammation in mice

21 January 2018

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Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice

21 January 2018

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Leptin antagonist ameliorates chronic colitis in IL-10⁻/⁻ mice

21 January 2018

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21 January 2018

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Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.

21 January 2018

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A human leptin mutant induces weight gain in normal mice

21 January 2018

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21 January 2018

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Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay

21 January 2018

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Selection of non-competitive leptin antagonists using a random nanobody-based approach

21 January 2018

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21 January 2018

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Crystal structure of the obese protein leptin-E100

21 January 2018

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Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/CJPP-2013-0012

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29 August 2017

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