Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? (Q38079791)

28 August 2017

title

Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? (English)

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28 August 2017

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Patrik Brundin

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28 August 2017

Charles Warren Olanow

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object named as

C Warren Olanow

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28 August 2017

language of work or name

English

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publication date

1 January 2013

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28 August 2017

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

31-40

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Cell biology. A unifying role for prions in neurodegenerative diseases

28 August 2017

cites work

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Shattuck lecture--neurodegenerative diseases and prions

21 January 2018

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21 January 2018

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Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

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Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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α-Synuclein in Lewy bodies

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors

21 January 2018

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Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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A critical evaluation of the Braak staging scheme for Parkinson's disease.

21 January 2018

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A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

21 January 2018

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Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease

21 January 2018

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Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Is Parkinson's disease a prion disorder?

21 January 2018

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Are synucleinopathies prion-like disorders?

21 January 2018

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Research in motion: the enigma of Parkinson's disease pathology spread

21 January 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

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Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

21 January 2018

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

21 January 2018

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Prion-like acceleration of a synucleinopathy in a transgenic mouse model

21 January 2018

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

21 January 2018

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

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Alpha-synuclein: normal function and role in neurodegenerative diseases.

21 January 2018

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Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

21 January 2018

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Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

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Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

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Endoproteolytic activity of the proteasome

21 January 2018

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A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

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Failure of the ubiquitin-proteasome system in Parkinson's disease

21 January 2018

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Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Parkinson's disease, proteins, and prions: milestones

21 January 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

21 January 2018

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Frequency of bowel movements and the future risk of Parkinson's disease

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

21 January 2018

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Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

21 January 2018

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α-Synuclein and protein degradation systems: a reciprocal relationship

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

21 January 2018

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Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.25373

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release_lkthhjkp75eapilmiqog552jdy

28 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/lkthhjkp75eapilmiqog552jdy

mapped directly with Wikidata item

24 November 2022

based on heuristic

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