Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers (Q37999463)

26 August 2017

title

Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers (English)

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26 August 2017

author

Bennard van Ravenzwaay

series ordinal

object named as

Bennard van Ravenzwaay

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26 August 2017

Robert Landsiedel

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26 August 2017

Christine Jäckh

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26 August 2017

Eric Fabian

series ordinal

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26 August 2017

publication date

3 April 2012

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Journal of Immunotoxicology

26 August 2017

published in

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

426-438

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HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.

26 August 2017

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Skin sensitization to p-phenylenediamine: the diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response

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Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis

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The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers.

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Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.

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Conjugated dienes as prohaptens in contact allergy: in vivo and in vitro studies of structure-activity relationships, sensitizing capacity, and metabolic activation

21 January 2018

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A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites

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Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes

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Elicitation response characteristics to mono- and to N,N'-diacetyl-para-phenylenediamine

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Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers

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Some distinctions between flavin-containing and cytochrome P450 monooxygenases

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Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes

21 January 2018

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Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency

21 January 2018

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Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin

21 January 2018

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Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens.

21 January 2018

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Epidermal CYP2 family cytochromes P450.

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Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds

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Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro.

21 January 2018

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Extrahepatic, differential expression of four classes of human alcohol dehydrogenase

21 January 2018

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A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

21 January 2018

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Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation.

21 January 2018

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Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach

21 January 2018

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Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.

21 January 2018

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Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens

21 January 2018

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Comparison of activities dependent on glutathione S-transferase and cytochrome P-450 IA1 in cultured keratinocytes and reconstructed epidermal models

21 January 2018

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Epidermal-skin-test 1,000 (EST-1,000)--a new reconstructed epidermis for in vitro skin corrosivity testing

21 January 2018

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Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin

21 January 2018

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Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models

21 January 2018

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Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Assessment of human epidermal model LabCyte EPI-MODEL for in vitro skin irritation testing according to European Centre for the Validation of Alternative Methods (ECVAM)-validated protocol

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

In vitro differentiation of skin sensitizers by cell signaling pathways

21 January 2018

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Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine.

21 January 2018

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Chemical toxicity testing in vitro using cytochrome P450-expressing cell lines, such as human CYP1B1.

21 January 2018

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STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS. II.

21 January 2018

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Integration of Langerhans-like cells into a human skin equivalent

21 January 2018

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Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid

21 January 2018

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Expression of N-acetyltransferase in monocyte-derived dendritic cells

21 January 2018

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Is benzoquinone the prohapten in cross-sensitivity among aminobenzene compounds?

21 January 2018

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Cutaneous metabolism of glycol ethers

21 January 2018

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Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin and full thickness model from Episkin

21 January 2018

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Nature and role of xenobiotic metabolizing esterases in rat liver, lung, skin and blood.

21 January 2018

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Skin: major target organ of allergic reactions to small molecular weight compounds

21 January 2018

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Elastin expression in a newly developed full-thickness skin equivalent

21 January 2018

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The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Expression and induction of cytochrome p450 isoenzymes in human skin equivalents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes

21 January 2018

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Drug-metabolizing enzymes in the skin of man, rat, and pig.

21 January 2018

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Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Distribution of xenobiotic metabolizing enzymes in skin

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Spatial quantification and classification of skin response following perturbation using organotypic skin cultures

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Assessment of the U937 cell line for the detection of contact allergens

21 January 2018

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Evaluation of cytochrome P450 activity in vitro, using dermal and hepatic microsomes from four species and two keratinocyte cell lines in culture

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Detection of haptenated proteins in organotypic human skin explant cultures exposed to dapsone

21 January 2018

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Dendritic cells and skin sensitization: biological roles and uses in hazard identification

21 January 2018

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Diphenylthiourea, a Common Rubber Chemical, Is Bioactivated to Potent Skin Sensitizers

21 January 2018

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Microdialysis for the evaluation of penetration through the human skin barrier - a promising tool for future research?

21 January 2018

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A new dendritic cell type suitable as sentinel of contact allergens

21 January 2018

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Characterization of T cell responses to fragrances

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Retinol and retinal metabolism. Relationship to the state of differentiation of cultured human keratinocytes

21 January 2018

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Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis.

21 January 2018

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Increase of CYP1B1 transcription in human keratinocytes and HaCaT cells after UV-B exposure

21 January 2018

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Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

T cells ignore aniline, a prohapten, but respond to its reactive metabolites generated by phagocytes: possible implications for the pathogenesis of toxic oil syndrome

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1547691X.2012.664578

10.3109/1547691X.2012.664578

21 January 2018

Identifiers

DOI

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26 August 2017

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