The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. (Q37996420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22443084%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches (English)

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26 January 2020

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26 January 2020

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26 January 2020

Monica Rosaria Maiello

series ordinal

object named as

Monica R Maiello

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26 January 2020

Amelia D'Alessio

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26 January 2020

Maria Pergameno

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26 January 2020

language of work or name

English

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publication date

23 March 2012

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Expert Opinion on Therapeutic Targets

26 January 2020

published in

1 reference

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26 January 2020

volume

16 Suppl 2

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26 January 2020

page(s)

S17-27

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The PI3K pathway as drug target in human cancer

26 January 2020

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Targeting the phosphoinositide 3-kinase pathway in cancer

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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Regulation of MAPKs by growth factors and receptor tyrosine kinases

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.

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Mutations of the BRAF gene in human cancer

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The RAF proteins take centre stage

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Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

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MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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A novel AKT3 mutation in melanoma tumours and cell lines

21 January 2018

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Colorectal cancer: mutations in a signalling pathway

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Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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10.1517/14728222.2011.639361

21 January 2018

Identifiers

DOI

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release_2pn6fi633javdfmhko3ck7lcwy

26 January 2020

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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