Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus. (Q37978926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22280315%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus (English)

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21 January 2020

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21 January 2020

Laia Salvadó

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21 January 2020

Lucía Serrano-Marco

series ordinal

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21 January 2020

Xavier Palomer

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21 January 2020

Manuel Vázquez-Carrera

series ordinal

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21 January 2020

language of work or name

English

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publication date

27 January 2012

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Expert Opinion on Therapeutic Targets

21 January 2020

published in

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21 January 2020

volume

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issue

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21 January 2020

page(s)

209-223

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A unified nomenclature system for the nuclear receptor superfamily

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Interleukin-6 depletion selectively improves hepatic insulin action in obesity

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.

21 January 2018

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Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice

21 January 2018

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Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth.

21 January 2018

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Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies

21 January 2018

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PPARβ/δ activation induces enteroendocrine L cell GLP-1 production

21 January 2018

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Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion

21 January 2018

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Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice

21 January 2018

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Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

21 January 2018

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

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Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice

21 January 2018

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HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events

21 January 2018

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Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial

21 January 2018

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The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient

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Atherogenic dyslipidemia: lipoprotein abnormalities and implications for therapy

21 January 2018

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21 January 2018

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Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

21 January 2018

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Dyslipidaemia in the metabolic syndrome and type 2 diabetes: pathogenesis, priorities, pharmacotherapies

21 January 2018

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Diabetic dyslipidaemia: from basic research to clinical practice.

21 January 2018

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Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

AMPK: an emerging drug target for diabetes and the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

PPARdelta regulates glucose metabolism and insulin sensitivity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2012.658370

The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition

21 January 2018

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Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes

21 January 2018

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PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Assessing the Association of Pioglitazone Use and Bladder Cancer Through Drug Adverse Event Reporting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.658370