Treatment of HER2-positive breast cancer: current status and future perspectives. (Q37962332)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22124364%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Treatment of HER2-positive breast cancer: current status and future perspectives (English)

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17 January 2020

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17 January 2020

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17 January 2020

Edith A Perez

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17 January 2020

Carlos L Arteaga

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17 January 2020

Mark X Sliwkowski

series ordinal

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17 January 2020

C Kent Osborne

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17 January 2020

language of work or name

English

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publication date

29 November 2011

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Nature Reviews Clinical Oncology

17 January 2020

published in

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17 January 2020

volume

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17 January 2020

issue

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17 January 2020

page(s)

16-32

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The discovery of receptor tyrosine kinases: targets for cancer therapy

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

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Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

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Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel

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A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies

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Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies

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A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

31 March 2020

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Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163.

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A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells

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Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.

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Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors

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Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent

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31 March 2020

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https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Tumour biology: herceptin acts as an anti-angiogenic cocktail.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

The role of HER2 in angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Integrating bevacizumab into the treatment of patients with early-stage breast cancer: focus on cardiac safety

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Jumping higher: is it still possible? The ALTTO trial challenge

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Preoperative chemotherapy plus lapatinib or trastuzumab or both in HER2-positive operable breast cancer (CHERLOB Trial).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Figitumumab (CP-751,871) for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Combined clinical trial results of a HER2/neu (E75) vaccine for the prevention of recurrence in high-risk breast cancer patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

The E75 HER2/neu peptide vaccine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Clinical and immunologic responses of HLA-A3+ breast cancer patients vaccinated with the HER2/neu-derived peptide vaccine, E75, in a phase I/II clinical trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Optimal dose and schedule of an HER-2/neu (E75) peptide vaccine to prevent breast cancer recurrence: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Results of the first phase 1 clinical trial of the HER-2/neu peptide (GP2) vaccine in disease-free breast cancer patients: United States Military Cancer Institute Clinical Trials Group Study I-04.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Results of the first phase I clinical trial of the novel II-key hybrid preventive HER-2/neu peptide (AE37) vaccine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2011.177

Gefitinib in combination with gemcitabine and vinorelbine in patients with metastatic breast cancer pre-treated with taxane and anthracycline chemotherapy: a phase I/II trial.

31 March 2020

1 reference

12 December 2020

Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials

1 reference

12 December 2020

Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells

1 reference

12 December 2020

Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells

1 reference

12 December 2020

Pilot trial of trastuzumab starting with or after the doxorubicin component of a doxorubicin plus paclitaxel regimen for women with HER2-positive advanced breast cancer

1 reference

12 December 2020

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions

1 reference

12 December 2020