Functions of Aβ, sAPPα and sAPPβ : similarities and differences (Q37965817)

26 August 2017

title

Functions of Aβ, sAPPα and sAPPβ : similarities and differences (English)

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26 August 2017

author name string

Stéphanie Chasseigneaux

series ordinal

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26 August 2017

Bernadette Allinquant

series ordinal

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26 August 2017

language of work or name

English

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publication date

7 December 2011

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Journal of Neurochemistry

26 August 2017

published in

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26 August 2017

volume

120 Suppl 1

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26 August 2017

page(s)

99-108

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Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

26 August 2017

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The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

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Newly generated neurons in the amygdala and adjoining cortex of adult primates.

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Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists

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LRP in amyloid-beta production and metabolism

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Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

21 January 2018

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The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo

21 January 2018

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Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway

21 January 2018

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Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

21 January 2018

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Secretion of nerve growth factor from septum stimulates neurite outgrowth and release of the amyloid protein precursor of Alzheimer's disease from hippocampal explants

21 January 2018

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Stimulated platelets release amyloid beta-protein precursor

21 January 2018

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sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

21 January 2018

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The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.

21 January 2018

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Upregulation of beta-amyloid precursor protein expression in glioblastoma multiforme

21 January 2018

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Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.

21 January 2018

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Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

21 January 2018

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Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.

21 January 2018

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Beta-amyloid monomers are neuroprotective.

21 January 2018

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

21 January 2018

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Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

21 January 2018

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Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

21 January 2018

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Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

The beta A4 amyloid precursor protein binding to copper.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

21 January 2018

1 reference

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A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

APP processing and synaptic function

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Amyloid beta-protein precursor is associated with extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Beta-amyloid precursor protein isoforms in various rat brain regions and during brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Regulation of amyloid precursor protein cleavage

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Abeta-degrading enzymes in Alzheimer's disease.

21 January 2018

1 reference

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Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

From differentiation to proliferation: The secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Homo- and heterodimerization of APP family members promotes intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Abeta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07584.X

10.1111/J.1471-4159.2011.07584.X

21 January 2018

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DOI

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26 August 2017

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