Squalene monooxygenase - a target for hypercholesterolemic therapy (Q37952270)

25 August 2017

title

Squalene monooxygenase - a target for hypercholesterolemic therapy (English)

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25 August 2017

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Leszek Rychlewski

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25 August 2017

Jan Barciszewski

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Małgorzata Giel-Pietraszuk

25 August 2017

series ordinal

object named as

Malgorzata Giel-Pietraszuk

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25 August 2017

Agnieszka Belter

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25 August 2017

Miroslawa Skupinska

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25 August 2017

Tomasz Grabarkiewicz

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25 August 2017

publication date

1 December 2011

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25 August 2017

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25 August 2017

volume

392

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25 August 2017

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25 August 2017

page(s)

1053-1075

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Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase

25 August 2017

cites work

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Inhibitors of squalene biosynthesis and metabolism

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The safety of statins in clinical practice

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A high-content RNAi-screening assay to identify modulators of cholesterol accumulation in Niemann-Pick type C cells

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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

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Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial

21 January 2018

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Effect of organic forms of selenium on delta-aminolevulinate dehydratase from liver, kidney, and brain of adult rats

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Effects of torcetrapib in patients at high risk for coronary events

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Inhibitors of fungal sterol synthesis: squalene-epoxidation and C-14-demethylation

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Gut-acting drugs for lowering cholesterol

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Speculations on the evolution of sterol structure and function

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Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease

21 January 2018

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Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial

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Receptor-Mediated Control of Cholesterol Metabolism

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

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Garlic: nature's protection against physiological threats

21 January 2018

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Placental defects are associated with male lethality in bare patches and striated embryos deficient in the NAD(P)H Steroid Dehydrogenase-like (NSDHL) Enzyme

21 January 2018

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Cholesterol sensing, trafficking, and esterification.

21 January 2018

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Squalene epoxidase as hypocholesterolemic drug target revisited

21 January 2018

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Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices

21 January 2018

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Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate

21 January 2018

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An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

21 January 2018

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Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

21 January 2018

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Novel nonstatin strategies to lower low-density lipoprotein cholesterol

21 January 2018

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Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Statins, fibrates, nicotinic acid, cholesterol absorption inhibitors, anion-exchange resins, omega-3 fatty acids: which drugs for which patients?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship to other flavoprotein oxidoreductases based on one NAD and two FAD fingerprints

21 January 2018

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine

21 January 2018

1 reference

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Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression

21 January 2018

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Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers

21 January 2018

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Squalene emulsions for parenteral vaccine and drug delivery

21 January 2018

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2011.195

The experimental squalene encephaloneuropathy in the rat.

21 January 2018

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Mechanisms of flavoprotein-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Update on the treatment of hypercholesterolemia, with a focus on hmg‐coa reductase inhibitors and combination regimens

21 January 2018

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A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium

21 January 2018

1 reference

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Regulation of the mevalonate pathway

21 January 2018

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Protein sensors for membrane sterols

21 January 2018

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(Aryloxy)methylsilane Derivatives as New Cholesterol Biosynthesis Inhibitors: Synthesis and Hypocholesterolemic Activity of a New Class of Squalene Epoxidase Inhibitors

21 January 2018

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

21 January 2018

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Gulf war syndrome: a toxic exposure? A systematic review

21 January 2018

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HMG-CoA reductase inhibitors for treatment of hypercholesterolemia

21 January 2018

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Medicinal plants: traditions of yesterday and drugs of tomorrow

21 January 2018

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Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng

21 January 2018

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Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Comparison of intestinal absorption of cholesterol with different plant sterols in man.

21 January 2018

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Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes

21 January 2018

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Plant lipocalins: violaxanthin de-epoxidase and zeaxanthin epoxidase

21 January 2018

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Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Regulation of microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Mammary cancer prevention by regular garlic and selenium-enriched garlic

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Simvastatin with or without ezetimibe in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

microRNAs and cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Good news for 'good' cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Getting a handle on Huntington's disease: the case for cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Progress in HDL-Based Therapies for Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Intensive lipid lowering with atorvastatin in patients with stable coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Pleiotropic effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Vaccination, squalene and anti-squalene antibodies: facts or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Detailed mechanism of squalene epoxidase inhibition by terbinafine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Mipomersen as a potential adjunctive therapy for hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

The epidemiologic basis for population-wide cholesterol reduction in the primary prevention of coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Lipid transport by mammalian ABC proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Beyond lipid lowering: What have we learned about the benefits of statins from the acute coronary syndromes trials?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Single amino acid exchanges in FAD-binding domains of squalene epoxidase of Saccharomyces cerevisiae lead to either loss of functionality or terbinafine sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

The mechanism of action of terbinafine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Statin therapy--Part II: Clinical considerations for cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Molecular cloning and expression of rat squalene epoxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

The Incremental Value of Lipids and Inflammatory Biomarkers in Determining Residual Cardiovascular Risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Protein prenylation: genes, enzymes, targets, and functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

21 January 2018

Safety of MF59 adjuvant

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Statins: mechanism of action and effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Inhibition of intestinal cholesterol absorption by ezetimibe in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Advancing therapy for hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.195

21 January 2018

Identifiers

DOI

10.1515/BC.2011.195

1 reference

25 August 2017

1 reference