Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia (Q37959298)

25 August 2017

title

Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia (English)

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25 August 2017

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Jan A Burger

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25 August 2017

publication date

1 March 2012

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Current hematologic malignancy reports

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

26-33

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Chronic lymphocytic leukemia

25 August 2017

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

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Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

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B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

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Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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Syk tyrosine kinase required for mouse viability and B-cell development

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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

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Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

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21 January 2018

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The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

21 January 2018

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Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

21 January 2018

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.

21 January 2018

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Bone marrow fibroblasts induce expression of PI3K/NF-kappaB pathway genes and a pro-angiogenic phenotype in CLL cells

21 January 2018

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CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

21 January 2018

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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

21 January 2018

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The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

21 January 2018

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ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

21 January 2018

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B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

21 January 2018

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CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia

21 January 2018

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Comprehensive assessment of chemokine expression profiles by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11899-011-0104-Z

Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta chemokine production in human B cells.

21 January 2018

1 reference

12 December 2020

Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling

1 reference

12 December 2020

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood

1 reference

12 December 2020

Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma

1 reference

12 December 2020

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

1 reference

12 December 2020

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

1 reference

12 December 2020

Role of CCL3 protein (monocyte inflammatory protein-1 alpha) in lymphoid malignancy.

1 reference

12 December 2020

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

1 reference

12 December 2020

The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival.

1 reference

12 December 2020

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

1 reference

12 December 2020

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma

1 reference

12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

12 December 2020

Survival of leukemic B cells promoted by engagement of the antigen receptor

1 reference

12 December 2020

10.1007/S11899-011-0104-Z

Identifiers

DOI

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25 August 2017

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