Cancer associated fibroblasts: the dark side of the coin. (Q37943818)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Cancer associated fibroblasts: the dark side of the coin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Paola Chiarugi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Paolo Cirri

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

language of work or name

1 reference

12 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Cancer Research

14 February 2020

published in

1 reference

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14 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

482-497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis

14 February 2020

cites work

1 reference

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Malignant cells facilitate lung metastasis by bringing their own soil

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Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

6 September 2017

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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

6 September 2017

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

6 September 2017

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Oxidative stress promotes myofibroblast differentiation and tumour spreading

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6 September 2017

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Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

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6 September 2017

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Hallmarks of cancer: interactions with the tumor stroma.

6 September 2017

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Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

6 September 2017

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The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling

6 September 2017

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Review of mesenchymal stem cells and tumors: executioner or coconspirator?

6 September 2017

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The extracellular matrix: not just pretty fibrils

6 September 2017

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Epithelial-mesenchymal transitions in development and disease

6 September 2017

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

6 September 2017

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

6 September 2017

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Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ

6 September 2017

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MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma

6 September 2017

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Pten in stromal fibroblasts suppresses mammary epithelial tumours

6 September 2017

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Chemokines in tumor-associated angiogenesis.

6 September 2017

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Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer

6 September 2017

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Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging

6 September 2017

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The basics of epithelial-mesenchymal transition

6 September 2017

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EMT: when epithelial cells decide to become mesenchymal-like cells

6 September 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 September 2017

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

6 September 2017

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An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

6 September 2017

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Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

6 September 2017

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Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

6 September 2017

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The metastatic niche: adapting the foreign soil

6 September 2017

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Metastasis: from dissemination to organ-specific colonization

6 September 2017

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Microenvironmental regulation of metastasis

6 September 2017

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Tumor suppressors and cell metabolism: a recipe for cancer growth

6 September 2017

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Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature

6 September 2017

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Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast

6 September 2017

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CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

6 September 2017

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Cancer-associated fibroblasts and tumor growth--bystanders turning into key players

6 September 2017

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Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis

6 September 2017

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CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

6 September 2017

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The (in) auspicious role of mesenchymal stromal cells in cancer: be it friend or foe.

6 September 2017

1 reference

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Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3

6 September 2017

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

6 September 2017

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Stromal myofibroblasts are drivers of invasive cancer growth

6 September 2017

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Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

6 September 2017

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Growth control by intracellular tension and extracellular stiffness

6 September 2017

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The epithelial-mesenchymal transition generates cells with properties of stem cells

6 September 2017

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No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

6 September 2017

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Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

6 September 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

6 September 2017

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Seprase: an overview of an important matrix serine protease

6 September 2017

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Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting

6 September 2017

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Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

6 September 2017

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

6 September 2017

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Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer

6 September 2017

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The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles

6 September 2017

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The myofibroblast: one function, multiple origins

6 September 2017

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Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?

6 September 2017

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Fibroblasts and myofibroblasts: their source, function and role in disease.

6 September 2017

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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

6 September 2017

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Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

6 September 2017

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A pericellular collagenase directs the 3-dimensional development of white adipose tissue

6 September 2017

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6 September 2017

Fibroblasts in cancer

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Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions.

6 September 2017

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

6 September 2017

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Tissue cells feel and respond to the stiffness of their substrate

6 September 2017

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Tensional homeostasis and the malignant phenotype

6 September 2017

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

6 September 2017

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Gene expression profiling reveals cross-talk between melanoma and fibroblasts: implications for host-tumor interactions in metastasis

6 September 2017

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

6 September 2017

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Cell type-specific response to growth on soft materials

6 September 2017

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Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

6 September 2017

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Molecular characterization of the tumor microenvironment in breast cancer

6 September 2017

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Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

6 September 2017

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

6 September 2017

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Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p.

6 September 2017

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Role of tissue stroma in cancer cell invasion

6 September 2017

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A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer

6 September 2017

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6 September 2017

Fibronectin at a glance

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Stem-cell origin of metastasis and heterogeneity in solid tumours

6 September 2017

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Myofibroblasts and mechano-regulation of connective tissue remodelling

6 September 2017

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Ligand binding to integrins

6 September 2017

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Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

6 September 2017

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

6 September 2017

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Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines

6 September 2017

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Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness

6 September 2017

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Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells

14 September 2017

1 reference

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Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

14 September 2017

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Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Ovarian cancer cells stimulate uPA gene expression in fibroblastic stromal cells via multiple paracrine and autocrine mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Paracrine effect of TGF-beta1 on downregulation of gap junctional intercellular communication between human dermal fibroblasts.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Human breast carcinoma desmoplasia is PDGF initiated.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186047

Aberrant type I and type III collagen gene expression in human breast cancer in vivo

3 December 2018

1 reference

12 December 2020

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis

1 reference

12 December 2020

Novel Function of Prostaglandins as Inducers of Gene Expression of HGF and Putative Mediators of Tissue Regeneration

1 reference

12 December 2020

Effect of growth factors on the activation of human Tenon's capsule fibroblasts

1 reference

12 December 2020

Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study

1 reference

12 December 2020

Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma

1 reference

12 December 2020

On the origin of cancer-associated fibroblasts

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

21984967

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984967%20AND%20SRC:MED&resulttype=core&format=json