Stathmin: a protein with many tasks. New biomarker and potential target in cancer (Q37942978)

25 August 2017

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title

Stathmin: a protein with many tasks. New biomarker and potential target in cancer (English)

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25 August 2017

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Barbara Belletti

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Gustavo Baldassarre

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language of work or name

English

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publication date

7 October 2011

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Expert Opinion on Therapeutic Targets

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

1249-1266

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Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin: A Tubulin-Sequestering Protein Which Forms a Ternary T2S Complex with Two Tubulin Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The 4 A X-ray structure of a tubulin:stathmin-like domain complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The oncoprotein 18/stathmin family of microtubule destabilizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Structure and thermodynamics of the tubulin-stathmin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Induction of stathmin expression during liver regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Induction of stathmin mRNA during liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin is expressed by the proliferating hepatocytes during liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin expression during newt retina regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a]anthracene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

E2F sites in the Op18 promoter are required for high level of expression in the human prostate carcinoma cell line PC-3-M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression of the Op18 gene is maintained by the CCAAT-binding transcription factor NF-Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

FoxM1 mediates resistance to herceptin and paclitaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

p21/CDKN1A mediates negative regulation of transcription by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Small non-coding RNAs in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Causes and consequences of microRNA dysregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Role of T198 modification in the regulation of p27(Kip1) protein stability and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

STAT3-stathmin interactions control microtubule dynamics in migrating T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent kinase-Gr

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin/Op18 phosphorylation is regulated by microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Control of Microtubule Dynamics by Oncoprotein 18: Dissection of the Regulatory Role of Multisite Phosphorylation during Mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of stathmin as a novel substrate for p38 delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Role for protein phosphatases in the cell-cycle-regulated phosphorylation of stathmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin inhibition enhances okadaic acid-induced mitotic arrest: a potential role for stathmin in mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The role of stathmin in the regulation of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin overexpression in 293 cells affects signal transduction and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Transforming properties of a Q18-->E mutation of the microtubule regulator Op18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin-tubulin interaction gradients in motile and mitotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Targeting stathmin in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Down-regulation of stathmin is required for TGF-beta inducible early gene 1 induced growth inhibition of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Systematic analysis of the transcriptional switch inducing migration of border cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Deregulation of FoxM1b leads to tumour metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin, a New Target of PRL-3 Identified by Proteomic Methods, Plays a Key Role in Progression and Metastasis of Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression of stathmin, a microtubule regulatory protein, is associated with the migration and differentiation of cultured early trophoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

stathmin, a gene enriched in the amygdala, controls both learned and innate fear

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin expression modulates migratory properties of GN-11 neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Rac activation by the T-cell receptor inhibits T cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Drosophila stathmin: a microtubule-destabilizing factor involved in nervous system formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Therapeutic interactions between stathmin inhibition and chemotherapeutic agents in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Cell cycle effects and induction of premitotic apoptosis by irofulven in synchronized cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of genes differentially expressed in association with acquired cisplatin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Proteomic analysis of cisplatin resistance in human ovarian cancer using 2-DE method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Heat shock proteins in cancer: chaperones of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin interaction with a putative kinase and coiled-coil-forming protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

STATs in cancer inflammation and immunity: a leading role for STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

The interplay between structure and function in intrinsically unstructured proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Correlation of oncoprotein 18/stathmin expression in human breast cancer with established prognostic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Prognostic significance of stathmin expression in correlation with metastasis and clinicopathological characteristics in human ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Stathmin immunoreactivity in phaeochromocytomas and paragangliomas: differential expression between benign and malignant neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Identification of novel biomarkers in pediatric primitive neuroectodermal tumors and ependymomas by proteome-wide analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25 344 genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

Expression of Stathmin in Localized Upper Urinary Tract Urothelial Carcinoma: Correlations With Prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.620951

10.1517/14728222.2011.620951

21 January 2018

Identifiers

DOI

1 reference

release_zje7soguhjc2vmr4nhxgj7jxke

25 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/zje7soguhjc2vmr4nhxgj7jxke

mapped directly with Wikidata item

24 November 2022

based on heuristic

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