Therapeutic targeting of tumor-stroma interactions. (Q37851151)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

review article

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title

Therapeutic targeting of tumor-stroma interactions (English)

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25 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Peter Barrett-Lee

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25 January 2020

Robert I Nicholson

series ordinal

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25 January 2020

language of work or name

English

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publication date

10 March 2011

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Expert Opinion on Therapeutic Targets

25 January 2020

published in

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25 January 2020

volume

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25 January 2020

issue

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25 January 2020

page(s)

609-621

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Fibroblast differentiation in wound healing and fibrosis

25 January 2020

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Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

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Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

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Endothelial-stromal interactions in angiogenesis

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Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

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Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

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High interstitial fluid pressure - an obstacle in cancer therapy

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3D collagen type I matrix inhibits the antimigratory effect of doxorubicin.

21 January 2018

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Integrins: bidirectional, allosteric signaling machines

21 January 2018

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Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

21 January 2018

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Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

21 January 2018

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beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

21 January 2018

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Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity

21 January 2018

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Matrix metalloproteinases and metastasis

21 January 2018

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External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas

21 January 2018

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{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.

21 January 2018

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Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy

21 January 2018

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Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

21 January 2018

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Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin

21 January 2018

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ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions.

21 January 2018

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An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression

21 January 2018

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Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts

21 January 2018

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Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and α5 Integrin Upregulation

21 January 2018

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The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells

21 January 2018

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Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling

21 January 2018

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Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway

21 January 2018

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Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention

21 January 2018

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Integrin (alpha6beta4) signals through Src to increase expression of S100A4, a metastasis-promoting factor: implications for cancer cell invasion

21 January 2018

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21 January 2018

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Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer.

21 January 2018

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Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.

21 January 2018

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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

21 January 2018

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Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model

21 January 2018

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Integrins as target: first phase III trial launches, but questions remain

21 January 2018

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A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanoma

21 January 2018

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Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

21 January 2018

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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

21 January 2018

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Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

21 January 2018

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Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

21 January 2018

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In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

21 January 2018

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Radical causes of cancer.

21 January 2018

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

21 January 2018

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Distinct role of macrophages in different tumor microenvironments

21 January 2018

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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

21 January 2018

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Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy

21 January 2018

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Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

21 January 2018

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Role of tumor-associated macrophages in tumor progression and invasion

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.561201

Targeting tumour-associated macrophages

21 January 2018

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Macrophages define the invasive microenvironment in breast cancer

21 January 2018

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Macrophage polarization in tumour progression

21 January 2018

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The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

21 January 2018

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer

21 January 2018

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Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.

21 January 2018

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The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

21 January 2018

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High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors

21 January 2018

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Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

21 January 2018

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Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue

21 January 2018

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Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production

21 January 2018

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NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

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"Re-educating" tumor-associated macrophages by targeting NF-kappaB.

21 January 2018

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

21 January 2018

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Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines

21 January 2018

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Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

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Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and Is More Effective When Combined with Dasatinib

21 January 2018

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Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

21 January 2018

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3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226.

21 January 2018

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Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

21 January 2018

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beta1 integrin targeting to enhance radiation therapy

21 January 2018

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Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion

21 January 2018

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Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors.

21 January 2018

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Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study

21 January 2018

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Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

21 January 2018

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Integrins and signal transduction

21 January 2018

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10.1517/14728222.2011.561201

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21388336%20AND%20SRC:MED&resulttype=core&format=json