Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect (Q37812619)

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English	Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 August 2017

Protein damage in diabetes and uremia--identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect (English)

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Europe PubMed Central

PubMed publication ID

23 August 2017

pathophysiology

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based on heuristic

inferred from title

Paul J Thornalley

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Paul J Thornalley

1

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author name string

Naila Rabbani

2

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Europe PubMed Central

PubMed publication ID

23 August 2017

publication date

29 November 2010

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Europe PubMed Central

PubMed publication ID

23 August 2017

Free Radical Research

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Europe PubMed Central

PubMed publication ID

23 August 2017

45

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

89-100

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Advanced glycation endproducts: what is their relevance to diabetic complications?

1 reference

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Highlights and hotspots of protein glycation in end-stage renal disease

1 reference

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Oxidants, oxidative stress and the biology of ageing

1 reference

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Protein tyrosine nitration--an update

1 reference

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A protein microarray-based analysis of S-nitrosylation

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

1 reference

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21 January 2018

Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes.

1 reference

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21 January 2018

Profound mishandling of protein glycation degradation products in uremia and dialysis.

1 reference

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21 January 2018

Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes

1 reference

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Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

1 reference

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21 January 2018

Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy

1 reference

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Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis

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Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

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Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women

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Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin

1 reference

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21 January 2018

Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment

1 reference

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21 January 2018

Enhanced carbonyl stress in a subpopulation of schizophrenia

1 reference

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Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase

1 reference

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21 January 2018

Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells

1 reference

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Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins

1 reference

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21 January 2018

Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage

1 reference

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21 January 2018

Cloning, expression, and catalytic triad of recombinant arylformamidase

1 reference

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Identification of a denitrase activity against calmodulin in activated macrophages using high-field liquid chromatography--FTICR mass spectrometry.

1 reference

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21 January 2018

Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins

1 reference

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21 January 2018

Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome.

1 reference

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21 January 2018

Elimination of damaged proteins during differentiation of embryonic stem cells

1 reference

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Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors

1 reference

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A mechanism regulating proteolysis of specific proteins during renal tubular cell growth

1 reference

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21 January 2018

Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus

1 reference

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21 January 2018

Antioxidant status in J774A.1 macrophage cell line during chronic exposure to glycated serum.

1 reference

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Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome

1 reference

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21 January 2018

Proteasome inhibition in glyoxal-treated fibroblasts and resistance of glycated glucose-6-phosphate dehydrogenase to 20 S proteasome degradation in vitro.

1 reference

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21 January 2018

Quality control of mitochondria: protection against neurodegeneration and ageing

1 reference

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Comparison of pharmacokinetics between highly and mildly modified AGE proteins in mice

1 reference

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21 January 2018

Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification

1 reference

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21 January 2018

Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC.

1 reference

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21 January 2018

Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tande

1 reference

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Conventional antibody against Nepsilon-(carboxymethyl)lysine (CML) shows cross-reaction to Nepsilon-(carboxyethyl)lysine (CEL): immunochemical quantification of CML with a specific antibody

1 reference

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Determination of nitrotyrosine concentrations in plasma samples of diabetes mellitus patients by four different immunoassays leads to contradictive results and disqualifies the majority of the tests

1 reference

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Decoding signalling networks by mass spectrometry-based proteomics

1 reference

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Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection

1 reference

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Measurement of nitrotyrosine in plasma by immunoassays is fraught with danger: commercial availability is no guarantee of analytical reliability

1 reference

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Theodor Bücher Lecture. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and the 9th IUBMB conference in Budapest.

1 reference

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Aging: a theory based on free radical and radiation chemistry

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The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease

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Proteomic analysis of carbonylated proteins in two-dimensional gel electrophoresis using avidin-fluorescein affinity staining

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Methods for the determination and quantification of the reactive thiol proteome.

1 reference

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Quantitative proteome mapping of nitrotyrosines.

1 reference

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Detection of redox-based modification in two-dimensional electrophoresis proteomic separations

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Helical peptide models for protein glycation: proximity effects in catalysis of the Amadori rearrangement

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Thiol-based redox switches in eukaryotic proteins

1 reference

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Protein S-nitrosylation: purview and parameters

1 reference

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Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction

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Protein tyrosine nitration--functional alteration or just a biomarker?

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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

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Nrf2 signaling and cell survival

1 reference

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Protein turnover on the scale of the proteome.

1 reference

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Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species

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Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

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A fast method to predict protein interaction sites from sequences

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Structural basis of collagen recognition by integrin alpha2beta1

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The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens

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Get a ligand, get a life: integrins, signaling and cell survival

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RGD and other recognition sequences for integrins

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

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Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c

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Circulating endothelial cells are associated with future vascular events in hemodialysis patients.

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Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

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Protein tyrosine nitration in the mitochondria from diabetic mouse heart. Implications to dysfunctional mitochondria in diabetes

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The sites and topology of mitochondrial superoxide production

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C. elegans as model for the study of high glucose- mediated life span reduction

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Nonenzymatic glucosylation of lysine residues in albumin

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Dicarbonyl intermediates in the maillard reaction

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Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity

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Identifiers

10.3109/10715762.2010.534162

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

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