Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals (Q37818762)

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scientific article published on 06 December 2010

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English	Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals	scientific article published on 06 December 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 August 2017

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Europe PubMed Central

Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals (English)

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Europe PubMed Central

PubMed publication ID

23 August 2017

apoptotic process

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signal transduction

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21144894

19 November 2024

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21144894

19 November 2024

cellular senescence

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21144894

19 November 2024

author name string

Adnan Erol

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Europe PubMed Central

PubMed publication ID

23 August 2017

language of work or name

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21144894

19 November 2024

publication date

6 December 2010

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Europe PubMed Central

PubMed publication ID

23 August 2017

number of pages

6

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https://api.elsevier.com/content/article/PII:S0898656810003499?httpAccept=text/xml

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10.1016/J.CELLSIG.2010.11.023

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https://api.elsevier.com/content/article/PII:S0898656810003499?httpAccept=text/plain

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10.1016/J.CELLSIG.2010.11.023

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Cellular Signalling

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Europe PubMed Central

PubMed publication ID

23 August 2017

23

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Europe PubMed Central

PubMed publication ID

23 August 2017

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PubMed publication ID

23 August 2017

1076-1081

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Europe PubMed Central

PubMed publication ID

23 August 2017

The P53 pathway: what questions remain to be explored?

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Mitochondria, oxidative stress and cell death

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Coping with stress: multiple ways to activate p53.

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Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

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Switching from life to death: the Miz-ing link between Myc and p53.

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Escaping from the TGFbeta anti-proliferative control

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Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

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DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif

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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

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EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

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Raptor-rictor axis in TGFbeta-induced protein synthesis.

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The two TORCs and Akt.

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Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway

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The coordinate regulation of the p53 and mTOR pathways in cells

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

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Rictor is a novel target of p70 S6 kinase-1.

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TGF-beta: a new role for an old AktTOR.

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins

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The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1

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Running on empty: how p53 controls INS/IGF signaling and affects life span

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Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells

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Decision-making by p53 and mTOR.

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

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Another "Janus paradox" of p53: induction of cell senescence versus quiescence

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Program-like aging and mitochondria: instead of random damage by free radicals

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Myc, Cdk2 and cellular senescence: Old players, new game

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Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

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Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

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Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

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10.1016/J.CELLSIG.2010.11.023

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Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

23 August 2017

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