What have we learned from Drosophila models of Parkinson’s disease? (Q37796006)

23 August 2017

title

What have we learned from Drosophila models of Parkinson's disease? (English)

1 reference

23 August 2017

What have we learned from Drosophila models of Parkinson’s disease? (English)

1 reference

10.1016/S0079-6123(10)84001-4

DOI

https://api.crossref.org/works/10.1016/S0079-6123(10)84001-4

24 July 2024

0 references

1 reference

Ming Guo

1 reference

23 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20887867

24 July 2024

publication date

1 January 2010

1 reference

Progress in Brain Research

23 August 2017

published in

1 reference

23 August 2017

volume

184

1 reference

23 August 2017

page(s)

3-16

1 reference

The genome sequence of Drosophila melanogaster

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

From sequence to phenotype: reverse genetics in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Drosophila, the golden bug, emerges as a tool for human genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Toxin-induced models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Staging of brain pathology related to sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The role of parkin in familial and sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Genetic mouse models of parkinsonism: strengths and limitations

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Autophagy and the degradation of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Genetics of Parkinson's disease and parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The genetics of Parkinson's syndromes: a critical review

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Coupling cell growth, proliferation, and death. Hippo weighs in.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Caspase-dependent cell death in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The genetics of cell death: approaches, insights and opportunities in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Organellar vs cellular control of mitochondrial dynamics

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Aminergic neurons in the brain of blowflies and Drosophila: dopamine- and tyrosine hydroxylase-immunoreactive neurons and their relationship with putative histaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin-deficient mice are not a robust model of parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The PINK1/Parkin pathway regulates mitochondrial morphology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Genetic variation of Omi/HtrA2 and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Comparative genomics of the eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

ATP13A2 mutations (PARK9) cause neurodegeneration with brain iron accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Nonmotor manifestations of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The art and design of genetic screens: Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The mitochondrial serine protease HtrA2/Omi: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Emerging technologies for gene manipulation in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss of locus coeruleus neurons and reduced startle in parkin null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

The kinase domain of mitochondrial PINK1 faces the cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2984001-4

7 January 2021

10.1016/S0079-6123(10)84001-4

Identifiers

DOI

1 reference

23 August 2017

1 reference