Complex role of the HIF system in cardiovascular biology (Q37767377)

22 August 2017

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title

Complex role of the HIF system in cardiovascular biology (English)

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22 August 2017

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Gabor Czibik

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24 June 2010

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Journal of Molecular Medicine

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

1101-1111

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Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

22 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00109-010-0646-X

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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Differential metabolic consequences of fumarate hydratase and respiratory chain defects

21 January 2018

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Developmental response to hypoxia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-010-0646-X

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

21 January 2018

1 reference

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Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

21 January 2018

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Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology

21 January 2018

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Iron chelation improves endothelial function in patients with coronary artery disease.

21 January 2018

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Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0646-X

An enquiry into the role of cobalt in the heart disease of chronic beer drinkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0646-X

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

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12 December 2020

The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction.

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12 December 2020

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress

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12 December 2020

Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function.

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse

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12 December 2020

ROS signaling in systemic and cellular responses to chronic intermittent hypoxia

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12 December 2020

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

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12 December 2020

Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization

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12 December 2020

Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity.

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12 December 2020

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

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12 December 2020

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

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12 December 2020

Identification and functional analysis of CITED2 mutations in patients with congenital heart defects

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12 December 2020

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

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12 December 2020

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

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12 December 2020

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

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12 December 2020

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation

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12 December 2020

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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12 December 2020

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

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12 December 2020

Role and regulation of prolyl hydroxylase domain proteins

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12 December 2020

In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size

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12 December 2020

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

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12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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12 December 2020

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

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12 December 2020

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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12 December 2020

Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha

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12 December 2020

Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

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12 December 2020

Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience

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12 December 2020

Targeting gene expression to hypoxic tumor cells

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12 December 2020

The failing heart--an engine out of fuel

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12 December 2020

Autophagy in load-induced heart disease

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12 December 2020

Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.

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12 December 2020

Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes

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12 December 2020

Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

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12 December 2020

Early expression of angiogenesis factors in acute myocardial ischemia and infarction

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12 December 2020

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

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12 December 2020

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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12 December 2020

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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12 December 2020

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

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12 December 2020

Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication

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12 December 2020

Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor

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12 December 2020

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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12 December 2020

Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia

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12 December 2020

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

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12 December 2020

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

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12 December 2020

Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation

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12 December 2020

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS

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12 December 2020

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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12 December 2020

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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12 December 2020

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

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12 December 2020

Calmodulin kinase II inhibition protects against structural heart disease

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12 December 2020

Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice

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12 December 2020

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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12 December 2020

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

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12 December 2020

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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12 December 2020

Hypertension caused by chronic intermittent hypoxia--influence of chemoreceptors and sympathetic nervous system

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12 December 2020

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

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12 December 2020

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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12 December 2020

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

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12 December 2020

Myocardial toxicity of cobalt in the rat

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12 December 2020

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

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12 December 2020

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

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12 December 2020

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

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12 December 2020

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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12 December 2020

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 December 2020

Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients

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12 December 2020

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

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12 December 2020

HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia.

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12 December 2020

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

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12 December 2020

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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12 December 2020

Energy substrate metabolism in cardiac hypertrophy

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12 December 2020

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

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12 December 2020

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha

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12 December 2020

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

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12 December 2020

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

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12 December 2020

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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12 December 2020

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

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12 December 2020

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

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12 December 2020

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

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12 December 2020

Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

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12 December 2020

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

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12 December 2020

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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12 December 2020

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

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12 December 2020

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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12 December 2020

Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning

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12 December 2020

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

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12 December 2020

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

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12 December 2020

A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor.

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12 December 2020

Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.

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12 December 2020

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

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12 December 2020

Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart

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12 December 2020

Myocardial reperfusion injury.

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12 December 2020

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

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12 December 2020

Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein

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12 December 2020

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

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12 December 2020

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

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12 December 2020

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

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12 December 2020

The role of oxygen availability in embryonic development and stem cell function

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12 December 2020

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

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12 December 2020

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

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12 December 2020

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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12 December 2020

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

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12 December 2020

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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12 December 2020

10.1007/S00109-010-0646-X

Identifiers

DOI

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22 August 2017

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