New insights into the differentiation and function of T follicular helper cells. (Q37621244)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

review article

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title

New insights into the differentiation and function of T follicular helper cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Cecile King

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21 August 2017

publication date

1 November 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

11 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

page(s)

757-766

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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The germinal center reaction

31 March 2020

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Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation

31 March 2020

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Germinal centers without T cells

31 March 2020

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Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

31 March 2020

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In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

31 March 2020

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Imaging of germinal center selection events during affinity maturation

31 March 2020

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Maturation and dispersal of B-cell clones during T cell-dependent antibody responses

31 March 2020

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Thymus-marrow cell combinations. Synergism in antibody production

31 March 2020

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Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes

31 March 2020

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CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

31 March 2020

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Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

31 March 2020

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Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells

31 March 2020

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B cells alter the phenotype and function of follicular-homing CXCR5+ T cells

31 March 2020

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Unique gene expression program of human germinal center T helper cells

31 March 2020

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

31 March 2020

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Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

31 March 2020

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SAP-controlled T-B cell interactions underlie germinal centre formation

31 March 2020

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

31 March 2020

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Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

31 March 2020

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Cytokine-secreting follicular T cells shape the antibody repertoire

31 March 2020

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CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

31 March 2020

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Lymphoid reservoirs of antigen-specific memory T helper cells

31 March 2020

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A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

31 March 2020

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Is selection for TCR affinity a factor in cytokine polarization?

31 March 2020

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The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

31 March 2020

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Decision criteria for resolving isotype switching conflicts by B cells.

31 March 2020

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Visualization of specific B and T lymphocyte interactions in the lymph node

31 March 2020

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T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

31 March 2020

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Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

31 March 2020

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Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation

31 March 2020

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

31 March 2020

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Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

31 March 2020

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

31 March 2020

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Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

31 March 2020

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Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

31 March 2020

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OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

31 March 2020

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The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

31 March 2020

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

31 March 2020

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Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells

31 March 2020

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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

31 March 2020

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Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression

31 March 2020

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Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

31 March 2020

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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

31 March 2020

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The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

31 March 2020

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CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

31 March 2020

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Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

31 March 2020

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The CD40 antigen and its ligand

31 March 2020

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CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions

31 March 2020

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Functions of CD40 on B cells, dendritic cells and other cells

31 March 2020

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ICOS is essential for effective T-helper-cell responses

31 March 2020

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Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.

31 March 2020

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ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.

31 March 2020

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Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

31 March 2020

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Restoring function in exhausted CD8 T cells during chronic viral infection

31 March 2020

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Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

31 March 2020

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The IL-21 receptor augments Th2 effector function and alternative macrophage activation

31 March 2020

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

31 March 2020

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

31 March 2020

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T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

31 March 2020

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IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

31 March 2020

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

31 March 2020

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IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

31 March 2020

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Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.

31 March 2020

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IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.

31 March 2020

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Follicular helper T cells are required for systemic autoimmunity

31 March 2020

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SLAM receptors and SAP influence lymphocyte interactions, development and function

31 March 2020

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Plasticity of CD4+ T cell lineage differentiation.

31 March 2020

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

31 March 2020

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GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

31 March 2020

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

31 March 2020

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

31 March 2020

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Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

31 March 2020

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Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

31 March 2020

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

31 March 2020

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

31 March 2020

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Bcl6 mediates the development of T follicular helper cells

31 March 2020

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Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angio

31 March 2020

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Inhibition of Th2 differentiation and GATA-3 expression by BCL-6

31 March 2020

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Germinal-center organization and cellular dynamics

31 March 2020

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In vivo imaging of germinal centres reveals a dynamic open structure

31 March 2020

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Human germinal center T cells are unique Th cells with high propensity for apoptosis induction.

31 March 2020

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31 March 2020

On immunological memory

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The changing preference of T and B cells for partners as T-dependent antibody responses develop

31 March 2020

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Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

31 March 2020

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IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

31 March 2020

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Persistence of memory B cells in mice deprived of T cell help.

31 March 2020

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Activation of Virus-specific Memory B Cells in the Absence of T Cell Help

31 March 2020

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Immune responses of IL-4, IL-5, IL-6 deficient mice.

31 March 2020

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IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo

31 March 2020

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T follicular helper (TFH) cells in normal and dysregulated immune responses

31 March 2020

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Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

31 March 2020

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T follicular helper cells differentiate from Th2 cells in response to helminth antigens

31 March 2020

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Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

31 March 2020

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Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches

31 March 2020

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Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses

31 March 2020

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Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells

31 March 2020

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Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus

31 March 2020

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Striking alteration of some populations of T/B cells in systemic lupus erythematosus: relationship to expression of CD62L or some chemokine receptors.

31 March 2020

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IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

31 March 2020

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Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

31 March 2020

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Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis

31 March 2020

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

31 March 2020

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B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells

31 March 2020

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Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.

31 March 2020

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

31 March 2020

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

31 March 2020

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Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centres: a neoplasia with origin in the outer zone of the germinal centre? Clinicopathological and immunohistochemical study of 10 cases with follicular T-cell markers

31 March 2020

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Peripheral T-Cell Lymphoma With Follicular Involvement and a CD4+/bcl-6+ Phenotype

31 March 2020

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Molecular classification of T-cell lymphomas

31 March 2020

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Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells

31 March 2020

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Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma

31 March 2020

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Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified

31 March 2020

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Angioimmunoblastic T-cell lymphoma

31 March 2020

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Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma

31 March 2020

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Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers.

31 March 2020

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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

31 March 2020

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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

31 March 2020

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T cells within germinal centers are specific for the immunizing antigen

31 March 2020

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12 December 2020

Heterogeneity of helper/inducer T lymphocytes. IV. Stimulation of resting and activated B cells by Th1 and Th2 clones

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12 December 2020

Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

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12 December 2020

Spontaneous formation of germinal centers in autoimmune mice.

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12 December 2020

Identifiers

DOI

10.1038/NRI2644

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19855402%20AND%20SRC:MED&resulttype=core&format=json

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11 February 2020

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24 November 2022

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