The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells (Q37608462)

21 August 2017

The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells (English)

1 reference

21 August 2017

1 reference

Eric Haines

1 reference

21 August 2017

Caroline Saucier

series ordinal

1 reference

21 August 2017

Audrey Claing

series ordinal

1 reference

21 August 2017

language of work or name

English

0 references

publication date

9 January 2014

1 reference

Journal of Biological Chemistry

21 August 2017

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21 August 2017

289

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21 August 2017

1 reference

21 August 2017

5687-5703

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describes a project that uses

21 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3937643/fullTextXML

inferred from PubMed Central ID database lookup

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Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Molecular Cloning of the Mousegrb2Gene: Differential Interaction of the Grb2 Adaptor Protein with Epidermal Growth Factor and Nerve Growth Factor Receptors

23 August 2017

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The PTB domain: a new protein module implicated in signal transduction

23 August 2017

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

23 August 2017

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Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver

23 August 2017

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

23 August 2017

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

P66Shc-rac1 pathway-mediated ROS production and cell migration is downregulated by ascorbic acid.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Tyrosine-317 of p52(Shc) mediates androgen-stimulated proliferation signals in human prostate cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Activation of Ras by receptor tyrosine kinases

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

p66(Shc) and Ras: controlling anoikis from the inside-out

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

Epidermal Growth Factor: Chemical and Biological Characterization,

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937643

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.516047

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M113.516047

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons

21 January 2018

1 reference

12 December 2020

The value of the human epidermal growth factor receptor-2 (HER2) as a prognostic marker

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12 December 2020

p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer

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12 December 2020

Overexpression of the Grb2 gene in human breast cancer cell lines

1 reference

12 December 2020

Grb2 overexpression in nuclei and cytoplasm of human breast cells: a histochemical and biochemical study of normal and neoplastic mammary tissue specimens

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12 December 2020

Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas

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12 December 2020

Identifiers

DOI

10.1074/JBC.M113.516047

1 reference

release_teujdjvr6vd3rfsrvyvgqwpbmy

21 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/teujdjvr6vd3rfsrvyvgqwpbmy

24 November 2022

mapped directly with Wikidata item

1 reference

21 August 2017

PubMed publication ID

24407288

1 reference