The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease (Q37564741)

21 August 2017

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title

The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease (English)

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chronic obstructive pulmonary disease

21 August 2017

0 references

1 reference

David A Ngan

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21 August 2017

Shawna V Vickerman

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21 August 2017

David J Granville

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21 August 2017

S F Paul Man

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21 August 2017

Don D Sin

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21 August 2017

publication date

1 June 2009

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Therapeutic advances in respiratory disease

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

113-129

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Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?

21 August 2017

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Prospects for new drugs for chronic obstructive pulmonary disease

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21 January 2018

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Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus

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CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.

21 January 2018

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Serpins prevent granzyme-induced death in a species-specific manner

21 January 2018

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Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice

21 January 2018

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Granzyme K: a novel mediator in acute airway inflammation

21 January 2018

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Extracellular granzymes: current perspectives

21 January 2018

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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

21 January 2018

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The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema

21 January 2018

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Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

The role of Granzyme B in atheromatous diseases

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

Death by a thousand cuts: granzyme pathways of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Inflammation of the airways and lung parenchyma in COPD: role of T cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

Mechanisms of granule-dependent killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention

21 January 2018

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https://api.crossref.org/works/10.1177%2F1753465809341965

The SERPINE2 gene is associated with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Matrix metalloproteinases in destructive pulmonary pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Killer cells in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granule-associated serine proteases: granzymes might not just be killer proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Altered T-cell phenotypes in chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Serpin structure, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Sources of autoantigens in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The nature of small-airway obstruction in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Elastin fragments drive disease progression in a murine model of emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Elastic fibres in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cell-matrix interactions in aging: role of receptors and matricryptins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Antielastin autoimmunity in tobacco smoking-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Increased intraepithelial T-cells in stable COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

A distributed nonlinear model of lung tissue elasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Recurrence of pulmonary emphysema in an alpha-1 proteinase inhibitor-deficient lung transplant recipient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The extracellular matrix as a cell survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Human and mouse granzyme A induce a proinflammatory cytokine response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The perforin mediated apoptotic pathway in lung injury and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Formation and function of the lytic NK-cell immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Oxidative stress and redox regulation of lung inflammation in COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Non-apoptotic functions of granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Contemporary management of chronic obstructive pulmonary disease: scientific review

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Putative role of neutrophil elastase in the pathogenesis of emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Extracellular matrix mechanics in lung parenchymal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Role of CXCR2 in cigarette smoke-induced lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Systemic consequences of COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Aging and cigarette smoke: fueling the fire

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Interferon gamma induction of pulmonary emphysema in the adult murine lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

Blunted T-lymphocyte response in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1753465809341965

21 January 2018

Identifiers

DOI

10.1177/1753465809341965

1 reference

21 August 2017

1 reference