Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. (Q37510143)

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28 February 2020

title

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice (English)

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28 February 2020

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28 February 2020

Gökhan S Hotamisligil

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28 February 2020

Brenna Baccaro

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28 February 2020

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Takahisa Nakamura

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28 February 2020

Masato Furuhashi

series ordinal

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28 February 2020

language of work or name

English

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publication date

22 October 2013

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28 February 2020

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28 February 2020

volume

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28 February 2020

issue

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28 February 2020

page(s)

526-534

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

28 February 2020

start time

30 August 2021

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April 2022 Public Data File from Crossref

copyrighted

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cites work

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

1 reference

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Novel role of PKR in inflammasome activation and HMGB1 release

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

23 August 2017

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

23 August 2017

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Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

23 August 2017

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Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase

23 August 2017

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Inflammation and metabolic disorders

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23 August 2017

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

23 August 2017

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IKK-beta links inflammation to obesity-induced insulin resistance

23 August 2017

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Small molecule inhibitors of the RNA-dependent protein kinase

23 August 2017

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A central role for JNK in obesity and insulin resistance

23 August 2017

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Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis

23 August 2017

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The cellular and signaling networks linking the immune system and metabolism in disease

23 August 2017

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6 September 2017

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Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans.

6 September 2017

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Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.

26 June 2018

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Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway.

2 September 2018

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

2 September 2018

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Modulation of the JNK pathway in liver affects insulin resistance status

2 September 2018

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2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24150608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB13-1019

1 reference

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28 February 2020

1 reference

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28 February 2020

PubMed publication ID

24150608

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24150608%20AND%20SRC:MED&resulttype=core&format=json