Targeting SOD1 reduces experimental non–small-cell lung cancer (Q37410635)

20 August 2017

Targeting SOD1 reduces experimental non–small-cell lung cancer (English)

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20 August 2017

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Andrea Glasauer

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20 August 2017

Laura A Sena

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20 August 2017

Lauren P Diebold

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20 August 2017

Andrew P Mazar

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20 August 2017

Navdeep S Chandel

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20 August 2017

language of work or name

English

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publication date

1 January 2014

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Journal of Clinical Investigation

20 August 2017

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20 August 2017

124

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20 August 2017

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20 August 2017

117-128

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describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3871252/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Mitochondria and cancer

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Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency

6 September 2017

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Changes in PSA kinetics predict metastasis- free survival in men with PSA-recurrent prostate cancer treated with nonhormonal agents: combined analysis of 4 phase II trials

6 September 2017

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Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

6 September 2017

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Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

6 September 2017

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A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer.

6 September 2017

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RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

6 September 2017

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

6 September 2017

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Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

6 September 2017

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Regulation of cancer cell metabolism

6 September 2017

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Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

6 September 2017

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Mitochondria and cell death: outer membrane permeabilization and beyond

6 September 2017

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

6 September 2017

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The landscape of somatic copy-number alteration across human cancers

6 September 2017

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Fluorescent protein-based redox probes

6 September 2017

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Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members

6 September 2017

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

6 September 2017

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

6 September 2017

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

6 September 2017

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Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors

6 September 2017

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6 September 2017

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Thiol chemistry and specificity in redox signaling

6 September 2017

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Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

6 September 2017

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

6 September 2017

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Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

6 September 2017

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Characterizing the cancer genome in lung adenocarcinoma

6 September 2017

1 reference

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Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

6 September 2017

1 reference

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

6 September 2017

1 reference

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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

6 September 2017

1 reference

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

6 September 2017

1 reference

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

14 September 2017

1 reference

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

14 September 2017

1 reference

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

28 September 2017

1 reference

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Inactivation of glutathione peroxidase by superoxide radical.

26 June 2018

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Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

26 June 2018

1 reference

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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871252

p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871252

Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871252

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871252

Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871252

2 September 2018

Identifiers

DOI

10.1172/JCI71714

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

24292713

1 reference