Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis? (Q37409478)

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23 January 2020

review article

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title

Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19271940%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

0 references

1 reference

1 reference

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23 January 2020

Michael K Racke

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23 January 2020

publication date

1 March 2009

1 reference

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

23 January 2020

published in

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23 January 2020

volume

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23 January 2020

issue

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23 January 2020

page(s)

319-321

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IL-12 unmasks latent autoimmune disease in resistant mice

23 January 2020

cites work

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

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Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

21 January 2018

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Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

21 January 2018

1 reference

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Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis

21 January 2018

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Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

21 January 2018

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Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale.

21 January 2018

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An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.

21 January 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

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CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.

21 January 2018

1 reference

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Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

21 January 2018

1 reference

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Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia

21 January 2018

1 reference

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