DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination (Q37397523)

20 August 2017

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title

DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination (English)

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20 August 2017

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Jason A Hackney

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20 August 2017

Shahram Misaghi

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20 August 2017

Kate Senger

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20 August 2017

Christopher Garris

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20 August 2017

Yonglian Sun

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20 August 2017

Maria N Lorenzo

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20 August 2017

Ali A Zarrin

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20 August 2017

publication date

1 January 2009

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20 August 2017

published in

Advances in Immunology

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20 August 2017

volume

101

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20 August 2017

page(s)

163-189

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AID from bony fish catalyzes class switch recombination

20 August 2017

cites work

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

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7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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7 January 2021

Immunology. Antibodies get a break

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7 January 2021

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

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7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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7 January 2021

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

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7 January 2021

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

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7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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7 January 2021

Molecular mechanisms of antibody somatic hypermutation.

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7 January 2021

Evolution of somatic hypermutation and gene conversion in adaptive immunity

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7 January 2021

Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences

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7 January 2021

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

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7 January 2021

DNA sequences at immunoglobulin switch region recombination sites

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7 January 2021

Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter

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7 January 2021

G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Comparative analyses of immunoglobulin genes: surprises and portents

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7 January 2021

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

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7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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7 January 2021

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

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7 January 2021

The plasticity of immunoglobulin gene systems in evolution

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7 January 2021

Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Shutdown of class switch recombination by deletion of a switch region control element.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Germinal centres: role in B-cell physiology and malignancy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Two levels of protection for the B cell genome during somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

The immunoglobulin heavy chain locus of the duck. Genomic organization and expression of D, J, and C region genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Immunoglobulins of the non-galliform birds: antibody expression and repertoire in the duck.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Immunoglobulin gene diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID and mismatch repair in antibody diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Somatic hypermutation: subverted DNA repair

1 reference

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7 January 2021

Somatic hypermutation shapes the antibody repertoire of memory B cells in humans

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

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https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Unique sequences are interspersed among tandemly repeated elements in the murine gamma 1 switch segment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Transcription-coupled events associating with immunoglobulin switch region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Antibody diversification by somatic mutation: from Burnet onwards

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Elucidation of IgH intronic enhancer functions via germ-line deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID is required for c-myc/IgH chromosome translocations in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Mechanism of R-loop formation at immunoglobulin class switch sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

The influence of transcriptional orientation on endogenous switch region function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Evolution of isotype switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Molecular aspects of somatic hypermutation of immunoglobulin genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Immunoglobulin genes: generating diversity with AID and UNG.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Strand-biased spreading of mutations during somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Evidence for an early appearance of modern post-switch immunoglobulin isotypes in mammalian evolution (II); cloning of IgE, IgG1 and IgG2 from a monotreme, the duck-billed platypus, Ornithorhynchus anatinus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Genome-wide somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

53BP1 is required for class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

B-cell self-tolerance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Predominant autoantibody production by early human B cell precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Genome analysis of the platypus reveals unique signatures of evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

IgH class switching and translocations use a robust non-classical end-joining pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Regulation of autoreactive antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Defective B cell tolerance checkpoints in systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

An evolutionarily conserved target motif for immunoglobulin class-switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Influence of switch region length on immunoglobulin class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2901005-5

7 January 2021

10.1016/S0065-2776(08)01005-5

Identifiers

DOI

1 reference

20 August 2017

1 reference