Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. (Q37354939)

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18 January 2020

review article

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3 November 2020

8 February 2021

Toll-like receptors and their role in carcinogenesis and anti-tumor treatment (English)

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18 January 2020

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3 November 2020

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8 February 2021

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Ewa Lech-Marańda

1 reference

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18 January 2020

Tadeusz Robak

1 reference

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18 January 2020

Anna Wolska

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18 January 2020

publication date

18 December 2008

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18 January 2020

3 November 2020

8 February 2021

Cellular & Molecular Biology Letters

3 references

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18 January 2020

3 November 2020

8 February 2021

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18 January 2020

issue

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18 January 2020

page(s)

248-272

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Leucine-rich repeats and pathogen recognition in Toll-like receptors.

18 January 2020

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Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2.

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Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors

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TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer

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Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis.

21 January 2018

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Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism.

21 January 2018

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Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state

21 January 2018

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The TNF receptor 1: a split personality complex

21 January 2018

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Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells

21 January 2018

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Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells.

21 January 2018

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Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

21 January 2018

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The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells

21 January 2018

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Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha

21 January 2018

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Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression

21 January 2018

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Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

21 January 2018

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Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells

21 January 2018

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

21 January 2018

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Inflammation as a tumor promoter in cancer induction

21 January 2018

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Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model

21 January 2018

1 reference

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Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

21 January 2018

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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

21 January 2018

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Novel toll-like receptor 9 agonist induces epidermal growth factor receptor (EGFR) inhibition and synergistic antitumor activity with EGFR inhibitors.

21 January 2018

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Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells

21 January 2018

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Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients

21 January 2018

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Discrimination of bacterial lipoproteins by Toll-like receptor 6

21 January 2018

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Inflammation-associated cancer: NF-kappaB is the lynchpin

21 January 2018

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CpG therapy is superior to BCG in an orthotopic bladder cancer model and generates CD4+ T-cell immunity

21 January 2018

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Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity

21 January 2018

1 reference

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The evolution of vertebrate Toll-like receptors

21 January 2018

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Synergy between In situ Cryoablation and TLR9 Stimulation Results in a Highly Effective In vivo Dendritic Cell Vaccine

21 January 2018

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Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

21 January 2018

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12 December 2020

Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells.

1 reference

12 December 2020

Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype

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12 December 2020

Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells

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12 December 2020

CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells

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12 December 2020

The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors

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12 December 2020

Proinflammatory response of human leukemic cells to dsRNA transfection linked to activation of dendritic cells

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12 December 2020

Cytotoxic combination of loxoribine with fludarabine and mafosfamide on freshly isolated B-chronic lymphocytic leukemia cells

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12 December 2020

Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma

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12 December 2020

Drosophila Toll and IL-1 receptor

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer

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12 December 2020

mRNA is an endogenous ligand for Toll-like receptor 3.

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12 December 2020

SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling

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12 December 2020

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity.

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12 December 2020

Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2.

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12 December 2020

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

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12 December 2020

Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma

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12 December 2020

Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant

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12 December 2020

Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing

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12 December 2020

Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help

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12 December 2020

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12 December 2020

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12 December 2020

Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation

1 reference

12 December 2020

Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer

1 reference

12 December 2020

CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice

1 reference

12 December 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

1 reference

12 December 2020

Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells

1 reference

12 December 2020

Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression

1 reference

12 December 2020

Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo

1 reference

12 December 2020

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling

1 reference

12 December 2020

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

1 reference

12 December 2020

An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

1 reference

12 December 2020

The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus

1 reference

12 December 2020

Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation

1 reference

12 December 2020

TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker

1 reference

12 December 2020

Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.

1 reference

12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

12 December 2020

Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN.

1 reference

12 December 2020

Imiquimod as an antiangiogenic agent.

1 reference

12 December 2020

Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB cascades, but not lipopolysaccharide-incorp

1 reference

12 December 2020

Inflammation and cancer

1 reference

12 December 2020

Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents

1 reference

12 December 2020

Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2.

1 reference

12 December 2020

Endotoxin-free heat-shock protein 70 fails to induce APC activation

1 reference

12 December 2020

Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70.

1 reference

12 December 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

1 reference

12 December 2020

Triggering of toll-like receptors 2 and 4 by Aspergillus fumigatus conidia in immortalized human corneal epithelial cells to induce inflammatory cytokines

1 reference

12 December 2020

T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides

1 reference

12 December 2020

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15

1 reference

12 December 2020

Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer

1 reference

12 December 2020

Mammalian Toll-like receptors: to immunity and beyond

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12 December 2020

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

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12 December 2020

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

12 December 2020

Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta

1 reference

12 December 2020

Immunologic and clinical effects of injecting mature peptide-loaded dendritic cells by intralymphatic and intranodal routes in metastatic melanoma patients

1 reference

12 December 2020

Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2.

1 reference

12 December 2020

Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.

1 reference

12 December 2020

Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides.

1 reference

12 December 2020

Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells

1 reference

12 December 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

1 reference

12 December 2020

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

1 reference

12 December 2020

Pattern-recognition receptor signaling initiated from extracellular, membrane, and cytoplasmic space.

1 reference

12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

12 December 2020

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors

1 reference

12 December 2020

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

1 reference

12 December 2020

Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells

1 reference

12 December 2020

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression

1 reference

12 December 2020

Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma

1 reference

12 December 2020

Intratumoural injection of the toll-like receptor-2/6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: a phase I/II trial

1 reference

12 December 2020

Therapeutic efficacy of antigen-specific vaccination and toll-like receptor stimulation against established transplanted and autochthonous melanoma in mice

1 reference

12 December 2020

Toll-like receptor 3 expressed by melanoma cells as a target for therapy?

1 reference

12 December 2020

Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation

1 reference

12 December 2020

A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages

1 reference

12 December 2020

Loxoribine Affects Fludarabine Activity on Freshly Isolated B-chronic Lymphocytic Leukemia Cells

1 reference

12 December 2020

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.

1 reference

12 December 2020

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

1 reference

12 December 2020

Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity.

1 reference

12 December 2020

Maturation, activation, and protection of dendritic cells induced by double-stranded RNA

1 reference

12 December 2020

Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

1 reference

12 December 2020

The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand

1 reference

12 December 2020

Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod

1 reference

12 December 2020

Interleukin-10 is upregulated in LPS tolerance

1 reference

12 December 2020

An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma

1 reference

12 December 2020

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

1 reference

12 December 2020

Control of intestinal inflammation by regulatory T cells

1 reference

12 December 2020

Phase 1 trial of a CpG oligodeoxynucleotide for patients with recurrent glioblastoma

1 reference

12 December 2020

Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14

1 reference

12 December 2020

Increased responsiveness to toll-like receptor 4 stimulation in peripheral blood mononuclear cells from patients with recent onset rheumatoid arthritis

1 reference

12 December 2020

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

1 reference

12 December 2020

Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line.

1 reference

12 December 2020

Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.

1 reference

12 December 2020

Evidence for T lymphocyte reactivity to the 65 kilodalton heat shock protein of mycobacterium in active Crohn's disease

1 reference

12 December 2020

The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells

1 reference

12 December 2020

10.2478/S11658-008-0048-Z

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19096763%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19096763%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

19096763

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