Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats (Q37259110)

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scientific article published on April 2013

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English	Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats	scientific article published on April 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

19 August 2017

Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats (English)

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Europe PubMed Central

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19 August 2017

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Edward D Levin

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19 August 2017

author name string

Yong Liu

1

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19 August 2017

Janell Richardson

2

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19 August 2017

Thao Tran

3

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19 August 2017

Nour Al-Muhtasib

4

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19 August 2017

Teresa Xie

5

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19 August 2017

Venkata Mahidhar Yenugonda

6

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19 August 2017

Hannah G Sexton

7

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19 August 2017

Amir H Rezvani

8

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19 August 2017

Niaz Sahibzada

10

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19 August 2017

Kenneth J Kellar

11

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19 August 2017

Milton L Brown

12

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19 August 2017

Yingxian Xiao

13

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19 August 2017

Mikell Paige

14

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19 August 2017

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publication date

1 April 2013

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19 August 2017

Journal of Medicinal Chemistry

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19 August 2017

56

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19 August 2017

7

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19 August 2017

3000-3011

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19 August 2017

Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors

1 reference

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Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

1 reference

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The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models

1 reference

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Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats

1 reference

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Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.

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Suicidal behavior and depression in smoking cessation treatments

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Innate C-H trifluoromethylation of heterocycles

1 reference

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Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.

1 reference

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6 September 2017

Nicotinic acetylcholine receptors containing the α4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption

1 reference

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6 September 2017

Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats

1 reference

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6 September 2017

Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption

1 reference

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Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats

1 reference

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6 September 2017

Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.

1 reference

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Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice

1 reference

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Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression

1 reference

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6 September 2017

Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice

1 reference

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Nicotinic receptors and nicotine addiction

1 reference

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Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression

1 reference

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6 September 2017

Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice

1 reference

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6 September 2017

Varenicline reduces alcohol self-administration in heavy-drinking smokers

1 reference

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6 September 2017

A preliminary benefit-risk assessment of varenicline in smoking cessation

1 reference

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6 September 2017

Desensitization of nicotinic acetylcholine receptors as a strategy for drug development

1 reference

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6 September 2017

Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809750

6 September 2017

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809750

6 September 2017

It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

1 reference

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6 September 2017

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking

1 reference

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6 September 2017

Subtypes of alcohol dependence in a nationally representative sample

1 reference

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6 September 2017

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

1 reference

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6 September 2017

Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them

1 reference

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Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

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6 September 2017

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.

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Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors

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6 September 2017

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

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6 September 2017

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

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The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells

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Actual Causes of Death in the United States, 2000

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Psychopharmacological interactions between nicotine and ethanol

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6 September 2017

Desensitization of neuronal nicotinic receptors

1 reference

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6 September 2017

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1 reference

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6 September 2017

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment

1 reference

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6 September 2017

The high-affinity nAChR partial agonists varenicline and sazetidine-A exhibit reinforcing properties in rats

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Nicotinic acetylcholine receptors in health and disease

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Nicotine activates and desensitizes midbrain dopamine neurons

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Effect of smoking history on [3H]nicotine binding in human postmortem brain

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Desensitization of nicotine-stimulated [3H]dopamine release from mouse striatal synaptosomes.

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26 June 2018

Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats

1 reference

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3 September 2018

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1 reference

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3 September 2018

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats

1 reference

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3 September 2018

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3 September 2018

Efficacy and tolerability of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, in a 12-week, randomized, placebo-controlled, dose-response study with 40-week follow-up for smoking cessation in Japanese smokers

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3 September 2018

Smoking cessation efficacy and safety of varenicline, an alpha4beta2 nicotinic receptor partial agonist

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3 September 2018

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3 September 2018

Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens

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3 September 2018

Involvement of nicotinic receptors in alcohol self-administration.

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3 September 2018

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1 reference

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3 September 2018

Effect of cigarette smoking on alcohol treatment outcome

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https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

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Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the desensitization produced by acetylcholine at the motor end-plate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of varying ethanol dose on cigarette consumption in healthy normal volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

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Desensitization of nicotine-stimulated 86Rb+ efflux from mouse brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23540678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM4000374

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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