p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model (Q37194848)

18 August 2017

p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model (English)

1 reference

18 August 2017

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Eliezer Masliah

1 reference

18 August 2017

Tasha G Bengoechea

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18 August 2017

Zhijiang Chen

series ordinal

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18 August 2017

Debra A O'Leary

series ordinal

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18 August 2017

Kuo-Fen Lee

series ordinal

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18 August 2017

language of work or name

English

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publication date

27 April 2009

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Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

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inferred from page(s)

published in

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18 August 2017

106

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18 August 2017

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18 August 2017

7870-7875

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describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2683130/fullTextXML

inferred from PubMed Central ID database lookup

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Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

6 September 2017

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p75NTR is positively promiscuous: novel partners and new insights

6 September 2017

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Sortilin is essential for proNGF-induced neuronal cell death

6 September 2017

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A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

6 September 2017

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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

6 September 2017

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Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

6 September 2017

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Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

6 September 2017

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

6 September 2017

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Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

6 September 2017

1 reference

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Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

6 September 2017

1 reference

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Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

6 September 2017

1 reference

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Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

6 September 2017

1 reference

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NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

6 September 2017

1 reference

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Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells

28 September 2017

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Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor.

28 September 2017

1 reference

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The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

26 June 2018

1 reference

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Dependence on p75 for innervation of some sympathetic targets

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

Impaired sympathetic nervous system response to cognitive effort in early Alzheimer's disease.

26 June 2018

1 reference

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Beta-amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons.

26 June 2018

1 reference

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Bace1 modulates myelination in the central and peripheral nervous system.

26 June 2018

1 reference

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Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

3 September 2018

1 reference

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

3 September 2018

1 reference

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p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

3 September 2018

1 reference

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Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin

3 September 2018

1 reference

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Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

p75 is important for axon growth and schwann cell migration during development.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683130

Organization of the sympathetic postganglionic innervation of the rat heart

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19416837

12 December 2020

inferred from PubMed ID database lookup

p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19416837

12 December 2020

inferred from PubMed ID database lookup

The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19416837

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0901533106

1 reference

18 August 2017

0 references

1 reference

18 August 2017

PubMed publication ID

19416837

1 reference