IgE in allergy and asthma today (Q37095248)

18 August 2017

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title

IgE in allergy and asthma today (English)

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18 August 2017

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Hannah J Gould

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Brian J Sutton

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18 August 2017

publication date

1 March 2008

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Nature Reviews Immunology

18 August 2017

published in

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

205-217

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18 August 2017

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Fetal exposure to intact immunoglobulin E occurs via the gastrointestinal tract

31 March 2020

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Advances in asthma, allergy mechanisms, and genetics in 2006.

31 March 2020

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The biology of IGE and the basis of allergic disease

31 March 2020

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The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation

31 March 2020

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Conformations of IgE bound to its receptor Fc epsilon RI and in solution

31 March 2020

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Dynamic conformations compared for IgE and IgG1 in solution and bound to receptors

31 March 2020

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The crystal structure of IgE Fc reveals an asymmetrically bent conformation

31 March 2020

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Bent Domain Structure of Recombinant Human IgE-Fc in Solution by X-ray and Neutron Scattering in Conjunction with an Automated Curve Fitting Procedure

31 March 2020

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Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains

31 March 2020

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Membrane immunoglobulins are stabilized by interchain disulfide bonds occurring within the extracellular membrane-proximal domain.

31 March 2020

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The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors

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Membrane IgE binds and activates Fc epsilon RI in an antigen-independent manner.

31 March 2020

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The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology

31 March 2020

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New developments in FcepsilonRI regulation, function and inhibition

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Crystal structure of the human high-affinity IgE receptor

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The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms

31 March 2020

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Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

31 March 2020

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Participation of the N-Terminal Region of Cε3 in the Binding of Human IgE to Its High-Affinity Receptor FcεRI

31 March 2020

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The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha

31 March 2020

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Insights into immunoglobulin E receptor signaling from structurally defined ligands

31 March 2020

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Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen

31 March 2020

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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

31 March 2020

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The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

31 March 2020

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Soluble CD23 monomers inhibit and oligomers stimulate IGE synthesis in human B cells.

31 March 2020

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Two peptides from CD23, including the inverse RGD sequence and its related peptide, interact with the MHC class II molecule

31 March 2020

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The structure of human CD23 and its interactions with IgE and CD21.

31 March 2020

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Two forms of the low-affinity Fc receptor for IgE differentially mediate endocytosis and phagocytosis: identification of the critical cytoplasmic domains

31 March 2020

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Intracellular trafficking of CD23: differential regulation in humans and mice by both extracellular and intracellular exons.

31 March 2020

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The B-cell binding site on human immunoglobulin E

31 March 2020

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CD21 is a ligand for CD23 and regulates IgE production

31 March 2020

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Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding

31 March 2020

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Structure of complement receptor 2 in complex with its C3d ligand

31 March 2020

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The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions

31 March 2020

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The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition

31 March 2020

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Regulatory roles of galectins in the immune response

31 March 2020

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Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes

31 March 2020

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X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution

31 March 2020

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CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18

31 March 2020

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Mouse CD23 regulates monocyte activation through an interaction with the adhesion molecule CD11b/CD18

31 March 2020

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The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23

31 March 2020

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αvβ5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein

31 March 2020

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Co-cultivation of mast cells and Fc epsilon RI alpha+ dendritic-like cells from human hip bone marrow

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IgE and Fc{epsilon}RI regulation

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Persistent IgE synthesis in the nasal mucosa of hay fever patients

31 March 2020

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Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics.

31 March 2020

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Regulation of mast-cell and basophil function and survival by IgE.

31 March 2020

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Local production and detection of (specific) IgE in nasal B-cells and plasma cells of allergic rhinitis patients

31 March 2020

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Limiting dilution analysis of the B cell compartment in human bone marrow

31 March 2020

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Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events

31 March 2020

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Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients.

31 March 2020

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S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination

31 March 2020

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Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis

31 March 2020

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Germinal-centre reactions in allergic inflammation

31 March 2020

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Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma

31 March 2020

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Competence and competition: the challenge of becoming a long-lived plasma cell

31 March 2020

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Is long-term humoral immunity in the mucosa provided by long-lived plasma cells? A question still open.

31 March 2020

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Regulation of IgA synthesis at mucosal surfaces

31 March 2020

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Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

31 March 2020

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Oral tolerance: immune mechanisms and treatment of autoimmune diseases

31 March 2020

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The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI).

31 March 2020

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Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy.

31 March 2020

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31 March 2020

The human IgE network

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IgE enhances specific antibody and T-cell responses in mice overexpressing CD23

31 March 2020

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Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells

31 March 2020

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Consequences of IgE/CD23-mediated antigen presentation in allergy

31 March 2020

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Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.

31 March 2020

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Antibody class switching differs among SJL, C57BL/6 and 129 mice

31 March 2020

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Polymorphism R62W results in resistance of CD23 to enzymatic cleavage in cultured cells

31 March 2020

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Eosinophils, allergy and parasites

31 March 2020

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IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.

31 March 2020

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Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo

31 March 2020

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Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma

31 March 2020

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Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression

31 March 2020

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CD23-mediated IgE transport across human intestinal epithelium: inhibition by blocking sites of translation or binding.

31 March 2020

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Antibody-mediated antigen sampling across intestinal epithelial barriers

31 March 2020

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Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress

31 March 2020

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Early expression of iepsilon, CD23 (FcepsilonRII), IL-4Ralpha, and IgE in the human fetus

31 March 2020

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CD23: an overlooked regulator of allergic disease.

31 March 2020

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Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex

31 March 2020

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Negative feedback regulation of IgE synthesis by murine CD23.

31 March 2020

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31 March 2020

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A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.

31 March 2020

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IgH class switching and translocations use a robust non-classical end-joining pathway

31 March 2020

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Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination

31 March 2020

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Internal IgH class switch region deletions are position-independent and enhanced by AID expression

31 March 2020

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Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells.

31 March 2020

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The road to the production of IgE is long and winding

31 March 2020

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The pharmacological basis of anti-IgE therapy

31 March 2020

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Convergent recognition of the IgE binding site on the high-affinity IgE receptor

31 March 2020

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Asthma genetics 2006: the long and winding road to gene discovery.

31 March 2020

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Discovering susceptibility genes for asthma and allergy

31 March 2020

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Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90).

31 March 2020

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The effects of roasting on the allergenic properties of peanut proteins

31 March 2020

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Presentation of allergen in different food preparations affects the nature of the allergic reaction--a case series

31 March 2020

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Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients

31 March 2020

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Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms

31 March 2020

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Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma.

31 March 2020

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The association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature

31 March 2020

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The allergic march from Staphylococcus aureus superantigens to immunoglobulin E.

31 March 2020

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Role of staphylococcal superantigens in airway disease.

31 March 2020

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Autosensitization as a pathomechanism in asthma

31 March 2020

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The cradle of IgE autoreactivity in atopic eczema lies in early infancy

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2273

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18 August 2017

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