The Keap1-Nrf2 system prevents onset of diabetes mellitus (Q37036376)

17 August 2017

The Keap1-Nrf2 system prevents onset of diabetes mellitus (English)

1 reference

17 August 2017

Akira Uruno

1 reference

17 August 2017

Yuki Furusawa

1 reference

17 August 2017

Yoko Yagishita

1 reference

17 August 2017

Toshiaki Fukutomi

1 reference

17 August 2017

Hiroyuki Muramatsu

1 reference

17 August 2017

Takaaki Negishi

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17 August 2017

Akira Sugawara

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17 August 2017

Thomas W Kensler

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17 August 2017

Masayuki Yamamoto

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17 August 2017

language of work or name

English

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publication date

28 May 2013

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Molecular and Cellular Biology

17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

2996-3010

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describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3719683/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors

29 September 2017

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Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

29 September 2017

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Bardoxolone methyl and kidney function in CKD with type 2 diabetes

29 September 2017

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Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

29 September 2017

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Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production

29 September 2017

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The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice

29 September 2017

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Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract

29 September 2017

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Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old.

29 September 2017

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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

29 September 2017

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Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

29 September 2017

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Nrf2: friend or foe for chemoprevention?

29 September 2017

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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

29 September 2017

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Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

29 September 2017

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

29 September 2017

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The role of exercise and PGC1alpha in inflammation and chronic disease

29 September 2017

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FKBP12.6 disruption impairs glucose-induced insulin secretion

29 September 2017

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Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

29 September 2017

1 reference

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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

29 September 2017

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Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

29 September 2017

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Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

29 September 2017

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Metabolic control through the PGC-1 family of transcription coactivators

29 September 2017

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

29 September 2017

1 reference

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

29 September 2017

1 reference

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Identification of polymorphisms in the promoter region of the human NRF2 gene

29 September 2017

1 reference

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

29 September 2017

1 reference

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

29 September 2017

1 reference

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A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma

29 September 2017

1 reference

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

29 September 2017

1 reference

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

29 September 2017

1 reference

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

29 September 2017

1 reference

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

29 September 2017

1 reference

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Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719683

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23716596

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.00225-13

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

23716596

1 reference