The promise of gene therapy for the treatment of epilepsy (Q37021317)

17 August 2017

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title

The promise of gene therapy for the treatment of epilepsy (English)

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17 August 2017

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Annamaria Vezzani

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17 August 2017

publication date

1 December 2007

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

1685-1692

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Brain-specific expression of an exogenous gene after i.v. administration

17 August 2017

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21 January 2018

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Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures

21 January 2018

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Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats

21 January 2018

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Transplants of cells engineered to produce GABA suppress spontaneous seizures

21 January 2018

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Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

21 January 2018

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Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo

21 January 2018

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Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

21 January 2018

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Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo

21 January 2018

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Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy.

21 January 2018

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Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.

21 January 2018

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Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.

21 January 2018

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Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats

21 January 2018

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21 January 2018

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Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control.

21 January 2018

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Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to epilepsy

21 January 2018

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Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

21 January 2018

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Brain inflammation in epilepsy: experimental and clinical evidence

21 January 2018

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Interleukin-1 and neuronal injury

21 January 2018

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Recombinant AAV-mediated gene delivery to the central nervous system.

21 January 2018

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Stem cells for the treatment of neurological disorders

21 January 2018

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Gene therapy against neurological insults: sparing neurons versus sparing function

21 January 2018

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The mechanism of neuroprotection by topiramate in an animal model of epilepsy.

21 January 2018

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Antiepileptic drugs and neuroprotection: current status and future roles

21 January 2018

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Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

21 January 2018

1 reference

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10.1586/14737175.7.12.1685

21 January 2018

Identifiers

DOI

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17 August 2017

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