Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms (Q36994267)

17 August 2017

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title

Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms (English)

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17 August 2017

Suzanne Eccles

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17 August 2017

Lenaic Paon

series ordinal

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17 August 2017

Jonathan Sleeman

series ordinal

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17 August 2017

publication date

6 November 2007

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Clinical & Experimental Metastasis

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

619-636

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Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium

17 August 2017

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Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis

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ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma

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Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis

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12 December 2020

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Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

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12 December 2020

L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis

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VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis.

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12 December 2020

High HSP90 expression is associated with decreased survival in breast cancer

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Molecular mechanisms of lymphatic vascular development

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12 December 2020

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

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12 December 2020

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression

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12 December 2020

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

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12 December 2020

Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2.

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12 December 2020

VEGF-C expression in breast cancer: clinical importance

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12 December 2020

Lymphatic dissemination of tumour cells and the formation of micrometastases

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12 December 2020

Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?

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Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up

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Absence of lymphangiogenesis in ductal breast cancer at the primary tumor site

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Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications

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Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma

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Predictors of recurrence in stage I (T1N0M0) breast carcinoma

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Molecular pathways for lymphangiogenesis and their role in human disease.

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Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival.

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12 December 2020

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

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12 December 2020

Tumor-Induced Activation of Lymphatic Endothelial Cells via Vascular Endothelial Growth Factor Receptor-2 Is Critical for Prostate Cancer Lymphatic Metastasis

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12 December 2020

Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study

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12 December 2020

Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.

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12 December 2020

Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis

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12 December 2020

Tumor-induced lymphangiogenesis: a target for cancer therapy?

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12 December 2020

Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphang

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12 December 2020

Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer

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12 December 2020

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12 December 2020

Paradigm shift of staging and treatment for early breast cancer in the sentinel lymph node era.

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12 December 2020

Lack of lymphangiogenesis during breast carcinogenesis

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12 December 2020

Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis

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12 December 2020

Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer

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12 December 2020

Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis

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12 December 2020

Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials.

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12 December 2020

Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5dione (1) as a Highly Selective VEGF-R2/3 Inhibitor

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12 December 2020

VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

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12 December 2020

Endostatin inhibits lymph node metastasis by a down-regulation of the vascular endothelial growth factor C expression in tumor cells

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12 December 2020

Differential activation of vascular genes by hypoxia in primary endothelial cells

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12 December 2020

Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270

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12 December 2020

Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages

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12 December 2020

Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor

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12 December 2020

Co-expression of vascular endothelial growth factor C (VEGF-C) and c-erbB2 in human breast carcinoma

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12 December 2020

Mechanisms of lymphangiogenesis: targets for blocking the metastatic spread of cancer

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12 December 2020

Host genetics influence tumour metastasis

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12 December 2020

Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: potential regulation by ligand-dependent degradation and HIF-1alpha

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12 December 2020

Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer

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12 December 2020

Expression of a CD44 variant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer.

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12 December 2020

High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer

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12 December 2020

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis

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12 December 2020

Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression.

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12 December 2020

Molecular regulation of microlymphatic formation and function: role of nitric oxide.

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12 December 2020

No common denominator for breast cancer lymph node metastasis

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12 December 2020

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

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12 December 2020

Biologic and clinical significance of lymphadenectomy

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12 December 2020

VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes

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12 December 2020

Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer

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12 December 2020

VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: impact on lymphangiogenesis and survival

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12 December 2020

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.

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12 December 2020

The role of nitric oxide in tumour progression

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12 December 2020

An approach for the treatment of penile carcinoma

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12 December 2020

Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients

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12 December 2020

Molecular mechanisms of tumor vascularization.

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12 December 2020

The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors

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12 December 2020

Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer

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12 December 2020

Involvement of chemokine receptors in breast cancer metastasis

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12 December 2020

COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer

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12 December 2020

Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway

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12 December 2020

Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer

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12 December 2020

A nonrandomized follow-up comparison between standard axillary node dissection and sentinel node biopsy in breast cancer

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12 December 2020

Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis

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12 December 2020

Analysis of paired primary lung and lymph node tumor cells: a model of metastatic potential by multiple genetic programs

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12 December 2020

Differential metastasis-associated gene analysis of prostate carcinoma cells derived from primary tumor and spontaneous lymphatic metastasis in nude mice with orthotopic implantation of PC-3M cells

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12 December 2020

Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats.

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12 December 2020

Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF)-C and -D and VEGF receptor 3 in invasive breast carcinoma

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12 December 2020

Pathways targeting tumor lymphangiogenesis

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12 December 2020

Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis

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12 December 2020

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

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12 December 2020

Tumor lymphangiogenesis and metastatic spread-new players begin to emerge.

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12 December 2020

Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer

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12 December 2020

Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study

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12 December 2020

Vascular endothelial growth factor-C and vascular endothelial growth factor-d messenger RNA expression in breast cancer: association with lymph node metastasis.

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12 December 2020

Lymphangiogenesis and tumor metastasis: myth or reality?

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12 December 2020

Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas.

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12 December 2020

Estrogen receptor positive breast cancer metastasis: altered hormonal sensitivity and tumor aggressiveness in lymphatic vessels and lymph nodes.

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12 December 2020

Current strategies for modulating lymphangiogenesis signalling pathways in human disease.

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12 December 2020

Gene expression profiling of tumor xenografts: In vivo analysis of organ‐specific metastasis

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12 December 2020

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

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12 December 2020

Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

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12 December 2020

Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective.

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12 December 2020

Expression of vascular endothelial growth factor-C and its receptor in invasive micropapillary carcinoma of the breast

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12 December 2020

Re: Influence of the new AJCC breast cancer staging system on sentinel lymph node positivity and false-negative rates

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12 December 2020

Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis.

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12 December 2020

Molecular regulation of angiogenesis and lymphangiogenesis

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12 December 2020

Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells

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12 December 2020

The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma

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12 December 2020

Gene expression predictors of breast cancer outcomes

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12 December 2020

Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model

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12 December 2020

Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer

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12 December 2020

Lymphangiogenesis, inflammation and metastasis.

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12 December 2020

Metachronous seeding of lymph node metastases in rats bearing the MT-100-TC mammary carcinoma: the effect of elective lymph node dissection

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12 December 2020

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

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12 December 2020

A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes

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12 December 2020

Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis.

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12 December 2020

Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients

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12 December 2020

CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer

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12 December 2020

Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer

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12 December 2020

Can we target the chemokine network for cancer therapeutics?

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12 December 2020

Can biology trump anatomy? Do all node-positive patients with breast cancer need chemotherapy?

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12 December 2020

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

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12 December 2020

The crucial role of macrophages in lymphangiogenesis

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12 December 2020

Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer

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12 December 2020

Role of lymphangiogenic factors in tumor metastasis

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12 December 2020

Targeting key steps in metastatic tumour progression

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12 December 2020

The lymph node as a bridgehead in the metastatic dissemination of tumors

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12 December 2020

Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics

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12 December 2020

Management of the axilla in women with breast cancer.

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12 December 2020

Chemokines, chemokine receptors, and cancer metastasis

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12 December 2020

Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study

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12 December 2020

Lymphatic zip codes in premalignant lesions and tumors

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12 December 2020

Metastasis: recent discoveries and novel treatment strategies

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12 December 2020

Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth

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12 December 2020

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

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12 December 2020

Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

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12 December 2020

Lymphangiogenesis does not occur in breast cancer

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12 December 2020

The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial

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12 December 2020

10.1007/S10585-007-9123-5

Identifiers

DOI

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17 August 2017

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