Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase (Q36884023)

16 August 2017

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title

Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase (English)

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16 August 2017

Amit V Pandey

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Christa E Flück

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16 August 2017

Catherine Nicolo

series ordinal

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16 August 2017

publication date

1 August 2007

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Fundamental and Clinical Pharmacology

16 August 2017

published in

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

399-410

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Apparent manifesting heterozygosity in P450 oxidoreductase deficiency and its effect on coexisting 21-hydroxylase deficiency.

16 August 2017

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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

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Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

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P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes

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Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study

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Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

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Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients.

21 January 2018

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Cytochrome P450 oxidoreductase deficiency in three patients initially regarded as having 21-hydroxylase deficiency and/or aromatase deficiency: diagnostic value of urine steroid hormone analysis

21 January 2018

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A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans

21 January 2018

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Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype

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Evidence for digenic inheritance in some cases of Antley-Bixler syndrome?

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Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes

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Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

21 January 2018

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Determination of the redox properties of human NADPH-cytochrome P450 reductase

21 January 2018

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NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer

21 January 2018

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Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

21 January 2018

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Chimeric Enzymes of Cytochrome P450 Oxidoreductase and Neuronal Nitric-oxide Synthase Reductase Domain Reveal Structural and Functional Differences

21 January 2018

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Glu-320 and Asp-323 Are Determinants of the CYP4A1 Hydroxylation Regiospecificity and Resistance to Inactivation by 1-Aminobenzotriazole

21 January 2018

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Yeast expression of animal and plant P450s in optimized redox environments

21 January 2018

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Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADPH-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s.

21 January 2018

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Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

21 January 2018

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Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17

21 January 2018

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Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

21 January 2018

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Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome

21 January 2018

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Genetic variation of human cytochrome p450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity

21 January 2018

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Kinetics of Ferric Cytochrome P450 Reduction by NADPH−Cytochrome P450 Reductase: Rapid Reduction in the Absence of Substrate and Variations among Cytochrome P450 Systems

21 January 2018

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Role of acidic residues in the interaction of NADPH-cytochrome P450 oxidoreductase with cytochrome P450 and cytochrome c.

21 January 2018

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The role of cytochrome P450 lysine residues in the interaction between cytochrome P450IA1 and NADPH-cytochrome P450 reductase

21 January 2018

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The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain.

21 January 2018

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Structure and function of cytochromes P450: a comparative analysis of three crystal structures

21 January 2018

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Association of cytochromes P450 with their reductases: opposite sign of the electrostatic interactions in P450BM-3 as compared with the microsomal 2B4 system

21 January 2018

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cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases

21 January 2018

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Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family

21 January 2018

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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

21 January 2018

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Role of Ser457 of NADPH-cytochrome P450 oxidoreductase in catalysis and control of FAD oxidation-reduction potential

21 January 2018

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Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

21 January 2018

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Structural and functional analysis of NADPH-cytochrome P-450 reductase from human liver: complete sequence of human enzyme and NADPH-binding sites

21 January 2018

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POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait

21 January 2018

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10.1111/J.1472-8206.2007.00520.X

21 January 2018

Identifiers

DOI

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16 August 2017

1 reference